Peptide Database

Peptide NameSLAY-screened peptide P5348

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length20 amino acids

Chemical FormulaC110H164N30O29S

DescriptionStandard

        PLLHLSPNMSEPTWTWRTVH
    

Molecular Weight2402.73 Da

Isoelectric Point (pI)7.33

Net Charge (pH 7.0)0.14

Net Charge (pH 7.4) -0.02

Charge Density (pH 7.0) 0.0068

GRAVY Index-0.54

Hydrophobic Moment 0.33

Boman Index0.08

Instability Index50.16

Aliphatic Index 73.00

Aromaticity 0.1000

Extinction Coeff. Reduced 11000.00

Extinction Coeff. Oxidized 11000.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 917.03

LogP -6.90

H-bond Donors 33.0

H-bond Acceptors 32.0

Rotatable Bonds 69.0

Heavy Atoms 170.0

Ring Count 9.0

Amide Bonds 20.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0164888 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Familyp53-derived

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/