Peptide Database

Peptide NameRFamide 2

Function Ontology

Neurological / Signaling ▸ Neuromodulation

Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide

Standard StatusStandard

Sequence Length7 amino acids

Chemical FormulaC43H63N11O12

DescriptionStandard

        ETNFLRF
    

Molecular Weight926.03 Da

Isoelectric Point (pI)6.10

Net Charge (pH 7.0)-0.16

Net Charge (pH 7.4) -0.33

Charge Density (pH 7.0) -0.0233

GRAVY Index-0.40

Hydrophobic Moment 0.56

Boman Index-0.09

Instability Index-6.86

Aliphatic Index 55.71

Aromaticity 0.2857

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 400.44

LogP -2.78

H-bond Donors 14.0

H-bond Acceptors 12.0

Rotatable Bonds 29.0

Heavy Atoms 66.0

Ring Count 2.0

Amide Bonds 7.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0084871 VERIFIED: NO

Provenance & Taxonomy

OrganismCallinectes sapidus [Animal]

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

C-TermAmidation

Bio-Activity Profile

Function

Neuropeptide

RECORD: Rec_0301201 VERIFIED: YES

Provenance & Taxonomy

OrganismCallinectes sapidus [Animal]

FamilyRFamide

Tax ID6763

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

C-TermAmidation

Bio-Activity Profile

Function

-

Half-LifeMammalian: 1 hour; Yeast: 30 min; E. coli: >10 hour

RECORD: Rec_0360860 VERIFIED: YES

Provenance & Taxonomy

Organismnot reported [other]

FamilyFMRFamide-like peptide

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

C-TermAmidation

Bio-Activity Profile

Function

Neuropeptide

Paper数据库级溯源文献：Wang Y, Wang M, Yin S, et al. NeuroPep: a comprehensive resource of neuropeptides. Database (Oxford). 2015:bav038. PMID 25931458; Bin Y, Zhang W, Tang W, et al. Prediction of Neuropeptides from Sequence Information Using Ensemble Classifier and Hybrid Features. J Proteome Res. 2020;19(9):3732-3740. PMID 32786686. PMID25931458;32786686 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25931458/

RECORD: Rec_0384522 VERIFIED: YES

Provenance & Taxonomy

OrganismCallinectes sapidus [Animal]

FamilyFMRFamide related peptide

Tax ID6763

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

C-TermAmidation

Bio-Activity Profile

Function

RFamide Neuropeptide Neuromodulator

PaperDiscovery and characterization of the Crustacean hyperglycemic hormone precursor related peptides (CPRP) and orcokinin neuropeptides in the sinus glands of the blue crab Callinectes sapidus using multiple tandem mass spectrometry techniques PMID21740068 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21740068/