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MYP_030402
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Basic Information
Lantibiotic peptide, Mersacidin
Antimicrobial
Antimicrobial ▸ Antibacterial
not Standard
20 amino acids
-
contains X representing unresolved or non-standard residue
Sequence
XXFXLPGGGGVXXLXXEXIX
Physicochemical Analysis
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Residue Composition
Amino Acid Composition
Chemical Descriptors
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0329018 VERIFIED: YES
Provenance & Taxonomy
Bacillus sp. HIL Y-85,54728 [Bacterium]
Structure & Mods
thioether-constrained peptide [Cyclic]
mixed L/D amino-acid peptide [Mixed]
C1-T2, T4-C12 and T13-C18: beta-methyllanthionine; T15-C20: S-(2-aminovinyl)-3-methyl-D-cysteine; S16: 2, 3-didehydroalanine
Bio-Activity Profile
Antimicrobial Antibacterial
Staphylococcus simulans 22
growth inhibition and cell lysis assay
PMID7793878
RECORD: Rec_0433335 VERIFIED: YES
Provenance & Taxonomy
Bacillus sp. HIL Y-85,54728 [Bacterium]
Lantibiotic
Structure & Mods
thioether-constrained peptide [Cyclic]
mixed L/D amino-acid peptide [Mixed]
C1-T2, T4-C12 and T13-C18: beta-methyllanthionine; T15-C20: S-(2-aminovinyl)-3-methyl-D-cysteine; S16: 2, 3-didehydroalanine
Bio-Activity Profile
Antimicrobial Antibacterial
Clostridium perfringens
4 μg/mL
MIC
PaperActivity of mersacidin, a novel peptide, compared with that of vancomycin, teicoplanin, and daptomycin. PMID1649577
RECORD: Rec_0433336 VERIFIED: YES
Provenance & Taxonomy
Bacillus sp. HIL Y-85,54728 [Bacterium]
Lantibiotic
Structure & Mods
thioether-constrained peptide [Cyclic]
mixed L/D amino-acid peptide [Mixed]
C1-T2, T4-C12 and T13-C18: beta-methyllanthionine; T15-C20: S-(2-aminovinyl)-3-methyl-D-cysteine; S16: 2, 3-didehydroalanine
Bio-Activity Profile
Antimicrobial Antibacterial
Propionibacterium acnes
8 μg/mL
MIC
PaperActivity of mersacidin, a novel peptide, compared with that of vancomycin, teicoplanin, and daptomycin. PMID1649577
RECORD: Rec_0433337 VERIFIED: YES
Provenance & Taxonomy
Bacillus sp. HIL Y-85,54728 [Bacterium]
Lantibiotic
Structure & Mods
thioether-constrained peptide [Cyclic]
mixed L/D amino-acid peptide [Mixed]
C1-T2, T4-C12 and T13-C18: beta-methyllanthionine; T15-C20: S-(2-aminovinyl)-3-methyl-D-cysteine; S16: 2, 3-didehydroalanine
Bio-Activity Profile
Antimicrobial Antibacterial
Staphylococcus aureus
8 μg/mL
MIC90
PaperActivity of mersacidin, a novel peptide, compared with that of vancomycin, teicoplanin, and daptomycin. PMID1649577
RECORD: Rec_0433338 VERIFIED: YES
Provenance & Taxonomy
Bacillus sp. HIL Y-85,54728 [Bacterium]
Lantibiotic
Structure & Mods
thioether-constrained peptide [Cyclic]
mixed L/D amino-acid peptide [Mixed]
C1-T2, T4-C12 and T13-C18: beta-methyllanthionine; T15-C20: S-(2-aminovinyl)-3-methyl-D-cysteine; S16: 2, 3-didehydroalanine
Bio-Activity Profile
Antimicrobial Antibacterial
Streptococcus pneumoniae
4-8 μg/mL
MIC
PaperActivity of mersacidin, a novel peptide, compared with that of vancomycin, teicoplanin, and daptomycin. PMID1649577
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