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MYP_030325
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Basic Information
Dermaseptin-1 (DStar 01)
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Antimicrobial ▸ Antifungal ▸ Anti-Candida
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytolysis / cell lysis ▸ Cytolytic activity
Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic
Standard
29 amino acids
C132H225N37O39
Standard
Sequence
GLWSKIKETGKEAAKAAGKAALNKIAEAV
Physicochemical Analysis
2954.42 Da
9.70
2.76
2.55
0.0953
-0.20
0.61
0.03
8.42
91.38
0.0345
5500.00
5500.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1245.48
-11.79
43.0
42.0
105.0
208.0
2.0
29.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0373559 VERIFIED: YES
Provenance & Taxonomy
Phyllomedusa trinitatis [Animal]
Dermaseptin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Non-hemolytic
PMID29980138 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29980138/
RECORD: Rec_0376354 VERIFIED: NO
Provenance & Taxonomy
Phyllomedusa trinitatis [Animal]
Dermaseptin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Antimicrobial
PMID29980138 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29980138/
RECORD: Rec_0400337 VERIFIED: YES
Provenance & Taxonomy
Phyllomedusa tarsius [Animal]
Dermaseptin
Structure & Mods
Single-chain peptide backbone represented as a linear sequence entry [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial
Escherichia coli
Evidence URLhttps://camp.bicnirrh.res.in/seqDisp.php?id=CAMPSQ4507
RECORD: Rec_0412498 VERIFIED: YES
Provenance & Taxonomy
Phyllomedusa tarsius [Animal]
Dermaseptin
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Antifungal
Staphylococcus aureus
Evidence URLhttps://dramp.cpu-bioinfor.org/browse/All_Information.php?dataset=General&id=DRAMP01673
RECORD: Rec_0414367 VERIFIED: YES
Provenance & Taxonomy
Phyllomedusa tarsius [Animal]
Dermaseptin
Structure & Mods
ribosomal mature linear peptide [Linear]
Gene-encoded natural peptide composed of standard L-amino acids [L]
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial
PaperS. Charpentier et al. / The Journal of Biological Chemistry 273 (1998) 14690-14697. Structure, synthesis, and molecular cloning of dermaseptins B, a family of skin peptide antibiotics Evidence URLhttps://www.uniprot.org/uniprotkb/P84921/entry
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