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MYP_030261
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Basic Information
TAT-Kα2
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antiviral
Antiviral ▸ Anti-Influenza virus
Antiviral ▸ Anti-Pneumovirus ▸ Anti-RSV
Enzyme modulation ▸ Enzyme inhibition ▸ Infection inhibition
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
22 amino acids
C126H212N44O28
Standard
Sequence
RRRQRRKKRGYGFVNLLFLVVE
Physicochemical Analysis
2791.31 Da
12.00
6.77
6.55
0.3075
-0.81
0.49
-0.48
99.65
92.73
0.1364
1490.00
1490.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1241.57
-9.77
47.0
35.0
98.0
198.0
3.0
23.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0404505 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Synthetic peptide
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Anti-Influenza virus Infection inhibition
Influenza virus (H5N2) A/bird/Korea/W81/2005
0.8 μM
IC50
Mammalian: 1 h; Yeast: 2 min; E. coli: 2 min
PaperInhibition of highly pathogenic avian influenza (HPAI) virus by a peptide derived from vFLIP through its direct destabilization of viruses | Moon HJ, Nikapitiya C, Lee HC, Park ME, Kim JH, Kim TH, Yoon JE, Cho WK, Ma JY, Kim CJ, Jung JU, Lee JS. | Sci Rep. 2017 Jul 7;7(1):4875. | DOI:10.1038/s41598-017-04777-4 | PMID:28687749 PMID28687749 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28687749/
RECORD: Rec_0418297 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
toxicity against MDCK cells up to 100 μM
100 μM
Cytotoxicity
PaperPubMed PMID: 28687749 PMID28687749 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28687749/
RECORD: Rec_0423559 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Synthetic peptide
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Anti-Influenza virus Infection inhibition
Influenza virus (H9N2) A/Chicken/Korea/116/2004
0.7 μM
IC50
Mammalian: 1 h; Yeast: 2 min; E. coli: 2 min
PaperInhibition of highly pathogenic avian influenza (HPAI) virus by a peptide derived from vFLIP through its direct destabilization of viruses | Moon HJ, Nikapitiya C, Lee HC, Park ME, Kim JH, Kim TH, Yoon JE, Cho WK, Ma JY, Kim CJ, Jung JU, Lee JS. | Sci Rep. 2017 Jul 7;7(1):4875. | DOI:10.1038/s41598-017-04777-4 | PMID:28687749 PMID28687749 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28687749/
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