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MYP_030254
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Basic Information
P-113
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Anti-biofilm ▸ Biofilm inhibition
Antimicrobial ▸ Antifungal
Antiviral
Therapeutic / Biomedical activity ▸ Dermatology / Cosmetic bioactivity ▸ Skin aging modulation ▸ Anti-aging
Therapeutic / Biomedical activity ▸ Dermatology / Cosmetic bioactivity ▸ Skin aging modulation ▸ Anti-wrinkle
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
12 amino acids
C71H109N27O14
Standard
Sequence
AKRHHGYKRKFH
Physicochemical Analysis
1564.80 Da
11.17
5.05
4.71
0.4211
-2.28
0.38
-0.68
63.83
8.33
0.1667
1490.00
1490.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
691.55
-5.62
26.0
22.0
53.0
112.0
5.0
11.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0342269 VERIFIED: NO
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Anticancer
PaperAntiCP 2.0: an updated model for predicting anticancer peptides (benchmark provenance; exact sequence-level experiment paper unresolved here) | https://pubmed.ncbi.nlm.nih.gov/32770192/
RECORD: Rec_0350256 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
Histatin
9606
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antifungal
Pseudomonas aeruginosa clinical isolates from cystic fibrosis patients
3.1 μg/mL
MIC
PaperStructural characterization and antimicrobial activity of the Zn(II) complex with P113 (demegen), a derivative of histatin 5, Inorg. Chem. (2010) PMID20815365 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20815365/
RECORD: Rec_0402010 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
Defensin
9606
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal
Candida albicans ATCC 10231
3.1 μg/mL
MIC
PMID11302797;28851350 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11302797/
RECORD: Rec_0404999 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide; DSSP H 0.0%, E 0.0%, T 66.7%, C 33.3% [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Anticancer Antimicrobial
PaperCancerPPD: a database of anticancer peptides and proteins PMID25270878 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25270878/
RECORD: Rec_0406177 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
Defensin
9606
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal
Candida albicans HIV pt. isolate 207
3.1 μg/mL
MIC
PMID11302797;28851350 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11302797/
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