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MYP_030254
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Basic Information
P-113
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Anti-biofilm ▸ Biofilm inhibition
Antimicrobial ▸ Antifungal
Antiviral
Therapeutic / Biomedical activity ▸ Dermatology / Cosmetic bioactivity ▸ Skin aging modulation ▸ Anti-aging
Therapeutic / Biomedical activity ▸ Dermatology / Cosmetic bioactivity ▸ Skin aging modulation ▸ Anti-wrinkle
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
12 amino acids
C71H109N27O14
Standard
Sequence
AKRHHGYKRKFH
Physicochemical Analysis
1564.80 Da
11.17
5.05
4.71
0.4211
-2.28
0.38
-0.68
63.83
8.33
0.1667
1490.00
1490.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
691.55
-5.62
26.0
22.0
53.0
112.0
5.0
11.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0012838 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
Defensin
9606
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal
Candida albicans HIV pt. isolate 111
3.1 μg/mL
MIC
PMID11302797;28851350 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11302797/
RECORD: Rec_0015217 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
Defensin
9606
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal
Candida albicans HIV pt. isolate 443
3.1 μg/mL
MIC
PMID11302797;28851350 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11302797/
RECORD: Rec_0046752 VERIFIED: NO
Provenance & Taxonomy
Homo sapiens [Animal]
Histatin
9606
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antifungal Antiviral
Evidence URLhttps://dramp.cpu-bioinfor.org/browse/All_Information.php?dataset=General&id=DRAMP18081
RECORD: Rec_0048119 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
9606
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
Evidence URLhttps://patents.google.com/patent/US20060069022A1/en PatentUS 2006/0069022 A1
RECORD: Rec_0066784 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
Histatin
9606
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antifungal
Pseudomonas aeruginosa clinical isolates from cystic fibrosis patients
6.3 μg/mL
MIC90
PaperStructural characterization and antimicrobial activity of the Zn(II) complex with P113 (demegen), a derivative of histatin 5, Inorg. Chem. (2010) PMID20815365 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20815365/
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