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MYP_030251
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Basic Information
The K4 peptide
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
14 amino acids
C87H132N18O15
Standard
Sequence
KKKKPLFGLFFGLF
Physicochemical Analysis
1670.09 Da
10.48
3.76
3.55
0.2683
0.33
0.32
0.22
3.90
83.57
0.2857
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
536.91
1.09
18.0
19.0
56.0
120.0
5.0
13.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0010449 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Staphylococcus aureus
PMID19573572 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19573572/
RECORD: Rec_0058243 VERIFIED: YES
Provenance & Taxonomy
the APD database-aided design. [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-negative
Escherichia coli
40-80 μM
MIC
PMID19573572 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19573572/
RECORD: Rec_0074530 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
S. thyphimurium, Pseudomonas aeruginosa and Klebsiella pneumoniae
24-48 μM
MIC
PaperKKKKPLFGLFFGLF: a cationic peptide designed to exert antibacterial activity
RECORD: Rec_0123627 VERIFIED: YES
Provenance & Taxonomy
the APD database-aided design. [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-negative Cytotoxic
CHO-K1 cells
Cell viability assay
PMID19573572 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19573572/
RECORD: Rec_0141230 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide; DSSP H 0.0%, E 0.0%, T 35.7%, C 64.3% [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antibacterial Antimicrobial Anti-Gram-positive Anti-Gram-negative
PaperYADAMP: yet another database of antimicrobial peptides PMID22325123 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22325123/
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