Peptide Database

Peptide NameSynenkephalin

Function Ontology

Neurological / Signaling ▸ Analgesic/opioid activity ▸ Analgesic

Neurological / Signaling ▸ Analgesic/opioid activity ▸ Opioid

Neurological / Signaling ▸ Neuromodulation

Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide

Neurological / Signaling ▸ Pain modulation ▸ Pronociceptive activity

Regulatory peptide ▸ Biological modulation

Standard StatusStandard

Sequence Length34 amino acids

Chemical FormulaC168H264N44O58S

DescriptionStandard

        WETCKEFLKLSQLEIPQDGTSALRESSPEESHAL
    

Molecular Weight3860.22 Da

Isoelectric Point (pI)4.54

Net Charge (pH 7.0)-4.15

Net Charge (pH 7.4) -4.43

Charge Density (pH 7.0) -0.1220

GRAVY Index-0.72

Hydrophobic Moment 0.59

Boman Index-0.09

Instability Index74.31

Aliphatic Index 74.71

Aromaticity 0.0588

Extinction Coeff. Reduced 5500.00

Extinction Coeff. Oxidized 5500.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1653.34

LogP -17.34

H-bond Donors 57.0

H-bond Acceptors 56.0

Rotatable Bonds 129.0

Heavy Atoms 271.0

Ring Count 6.0

Amide Bonds 35.0

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.

2D CHEMICAL STRUCTURE

Drag to move

Drag to move. Use the buttons to zoom.

RECORD: Rec_0013851 VERIFIED: YES

Provenance & Taxonomy

OrganismFelis catus [Animal]

FamilySynenkephalin

Tax ID9685

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Analgesic Pronociceptive Neuropeptide Neuromodulator Receptor modulation

Half-LifeMammalian: 2.8 hour; Yeast: 3 min; E. coli: 2 min

RECORD: Rec_0078889 VERIFIED: YES

Provenance & Taxonomy

Organismnot reported [other]

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Neuropeptide

Paper数据库级溯源文献：Wang Y, Wang M, Yin S, et al. NeuroPep: a comprehensive resource of neuropeptides. Database (Oxford). 2015:bav038. PMID 25931458; Bin Y, Zhang W, Tang W, et al. Prediction of Neuropeptides from Sequence Information Using Ensemble Classifier and Hybrid Features. J Proteome Res. 2020;19(9):3732-3740. PMID 32786686. PMID25931458;32786686 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25931458/

RECORD: Rec_0223160 VERIFIED: NO

Provenance & Taxonomy

OrganismFelis catus [Animal]

FamilyOpioid

Tax ID9685

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Opioid Analgesic Neuromodulator