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MYP_030186
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Basic Information
I16R
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Standard
25 amino acids
C135H227N53O27
Standard
Sequence
FIHHIIGGLFSAGKARHRLIRRRRR
Physicochemical Analysis
3024.59 Da
12.00
8.02
7.66
0.3208
-0.49
0.61
-0.32
133.00
101.60
0.0800
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1327.31
-11.41
52.0
38.0
104.0
215.0
5.0
24.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0160999 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Pleurocidin
32630.0
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
Pseudomonas aeruginosa
512 μg/mL
MIC
PMID29040295 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29040295/
RECORD: Rec_0270065 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Pleurocidin
32630.0
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
Candida albicans
128 μg/mL
MIC
PMID29040295 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29040295/
RECORD: Rec_0300054 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Pleurocidin
32630.0
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Hemolytic
Mouse erythrocytes
25 μg/mL
Hemolysis
PMID29040295 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29040295/
RECORD: Rec_0352162 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antifungal Hemolytic
PaperHydrophobic residues are critical for the helix-forming, hemolytic and bactericidal activities of amphipathic antimicrobial peptide TP4. PLoS One. 2017 Oct 17;12(10):e0186442. doi: 10.1371/journal.pone.0186442. PMID: 29040295. PMID29040295 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29040295/
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