Peptide Database

Peptide NameSC24EK

Function Ontology

Antimicrobial

Antiviral

Antiviral ▸ Anti-HIV ▸ Anti-HIV-1

Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition

Standard StatusStandard

Sequence Length24 amino acids

Chemical FormulaC142H220N32O46

DescriptionStandard

        WEEWDKKIEEYTKKIEELIKKSEE
    

Molecular Weight3111.45 Da

Isoelectric Point (pI)4.82

Net Charge (pH 7.0)-3.22

Net Charge (pH 7.4) -3.45

Charge Density (pH 7.0) -0.1341

GRAVY Index-1.76

Hydrophobic Moment 0.69

Boman Index-0.37

Instability Index84.61

Aliphatic Index 65.00

Aromaticity 0.1250

Extinction Coeff. Reduced 12490.00

Extinction Coeff. Oxidized 12490.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1316.71

LogP -6.33

H-bond Donors 45.0

H-bond Acceptors 43.0

Rotatable Bonds 113.0

Heavy Atoms 220.0

Ring Count 5.0

Amide Bonds 23.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0202732 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyFusion-inhibitory peptide

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermAcetylation

C-TermAmidation

Bio-Activity Profile

Function

Antiviral Anti-HIV-1 Fusion inhibition

TargetHIV-1 NL4-3 | TZM-bl cells

Activity0.1076±0.008 μM

MethodIC50

Half-LifeMammalian: 2.8 h; Yeast: 3 min; E. coli: 2 min

PaperConserved Residue Asn-145 in the C-Terminal Heptad Repeat Region of HIV-1 gp41 is Critical for Viral Fusion and Regulates the Antiviral Activity of Fusion Inhibitors. | Geng X, Liu Z, Yu D, Qin B, Zhu Y, Cui S, Chong H, He Y. | Viruses. 2019 Jul 3;11(7):609. | DOI:10.3390/v11070609 | PMID:31277353 PMID31277353 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/31277353/

RECORD: Rec_0333879 VERIFIED: YES