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MYP_030052
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Basic Information
Unnamed
Antimicrobial
Antiviral
Antiviral ▸ Anti-HIV
Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition ▸ Fusion inhibitor
Standard
38 amino acids
C196H311N57O62
Standard
Sequence
TTWEAWDRAIAEYAARIEALLRALQEQQEKNEAALREL
Physicochemical Analysis
4457.91 Da
4.64
-3.58
-3.79
-0.0943
-0.64
0.62
-0.15
60.58
95.53
0.0789
12490.00
12490.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1976.67
-16.62
69.0
59.0
151.0
315.0
5.0
41.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0003623 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide; DSSP H 89.5%, E 0.0%, T 0.0%, C 10.5% [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Antimicrobial
PaperHIPdb: a database of experimentally validated HIV inhibiting peptides PMID23359817 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23359817/
RECORD: Rec_0024637 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
HIV fusion inhibitor
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Acetylation
Amidation
Conjugated with PEG(40KDa) through Lys-30
Bio-Activity Profile
Antimicrobial Antiviral
HIV-4
Rat plasma, human plasma: The half-life is 4.4 h
PaperSchneider EL, Ashley GW, Dillen L, Stoops B, Austin NE, Malcolm BA, Santi DV. Half-life extension of the HIV-fusion inhibitor peptide TRI-1144 using a novel linker technology. Eur J Pharm Biopharm Eur J Pharm Biopharm. 2015 Jun;93:254-9. PMID:25900863 https://pubmed.ncbi.nlm.nih.gov/25900863/ PMID25900863 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25900863/
RECORD: Rec_0055615 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
HIV fusion inhibitor
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Acetylation
Amidation
Conjugated with PEG(40KDa) through Lys-30
Bio-Activity Profile
Antimicrobial Antiviral
HIV-2
Rat plasma, human plasma: The half-life is 34 h in rat plasma and 70 h in human plasma
PaperSchneider EL, Ashley GW, Dillen L, Stoops B, Austin NE, Malcolm BA, Santi DV. Half-life extension of the HIV-fusion inhibitor peptide TRI-1144 using a novel linker technology. Eur J Pharm Biopharm Eur J Pharm Biopharm. 2015 Jun;93:254-9. PMID:25900863 https://pubmed.ncbi.nlm.nih.gov/25900863/ PMID25900863 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25900863/
RECORD: Rec_0072903 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
HIV gp41 fusion inhibitor
32630.0
Structure & Mods
synthetic linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
Bio-Activity Profile
Antiviral Anti-HIV
HIV-1 IIIB
0.10 μg/mL
IC50
PaperNovel Methods of Synthesis for Therapeutic Antiviral Peptides Evidence URLhttps://patents.google.com/patent/US20100261876A1/en PatentUS 20100261876 A1
RECORD: Rec_0085805 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Acetylation
Amidation
Conjugated with MorphSO2 conjugate throµgh Lys-30
Bio-Activity Profile
Antiviral Anti-HIV
LC-MS/MS
Intravenously administered to Sprague–Dawley rats, in vivo; 158400 s
PMID25900863 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25900863/
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