Peptide Database

Peptide NameDefensin beta 4A (Beta-defensin 2) (BD-2) (Defensin; beta 2) (RhBD-2)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antifungal

Antimicrobial ▸ Antifungal ▸ Anti-Candida

Immunology ▸ Immune cell migration ▸ Chemotactic peptide

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Standard StatusStandard

Sequence Length64 amino acids

Chemical FormulaC328H516N82O75S8

DescriptionStandard

        MRVLYLLFSFLFIFLMPLPGVFGGIGDPVTCLKNGAICHPVFCPRRYKQIGTCGLPGTKCCKKP
    

Molecular Weight7064.63 Da

Isoelectric Point (pI)9.46

Net Charge (pH 7.0)6.52

Net Charge (pH 7.4) 6.16

Charge Density (pH 7.0) 0.1019

GRAVY Index0.56

Hydrophobic Moment 0.52

Boman Index0.25

Instability Index38.96

Aliphatic Index 92.81

Aromaticity 0.1250

Extinction Coeff. Reduced 2980.00

Extinction Coeff. Oxidized 3355.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 2424.43

LogP -13.68

H-bond Donors 88.0

H-bond Acceptors 91.0

Rotatable Bonds 221.0

Heavy Atoms 493.0

Ring Count 16.0

Amide Bonds 65.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0358482 VERIFIED: YES

Provenance & Taxonomy

OrganismMacaca mulatta [Animal]

FamilyBeta-defensin; Defensin

Tax ID9544

Structure & Mods

Configdisulfide-constrained cyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

Disulfidedisulfide bond; sites not specified

Bio-Activity Profile

Function

Antimicrobial Defensin Antifungal Anti-Candida Chemotactic Non-hemolytic

TargetCandida albicans