Peptide Database

Peptide NameStRIP11

Function Ontology

Anticancer

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length17 amino acids

Chemical FormulaC92H132N24O31

DescriptionStandard

        DDEREQFLYHSLSFNAV
    

Molecular Weight2070.17 Da

Isoelectric Point (pI)4.31

Net Charge (pH 7.0)-3.15

Net Charge (pH 7.4) -3.41

Charge Density (pH 7.0) -0.1851

GRAVY Index-0.73

Hydrophobic Moment 0.19

Boman Index-0.10

Instability Index23.56

Aliphatic Index 68.82

Aromaticity 0.1765

Extinction Coeff. Reduced 1490.00

Extinction Coeff. Oxidized 1490.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 915.57

LogP -8.61

H-bond Donors 31.0

H-bond Acceptors 29.0

Rotatable Bonds 67.0

Heavy Atoms 147.0

Ring Count 4.0

Amide Bonds 18.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0150453 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Confighydrocarbon-stapled side-chain cyclic peptide [Cyclic]

Chiralitynoncanonical stereochemical modification [Modified]

N-TermFluorescein labeling

C-TermNone

Other ModsStapled: Ⓧ(4) and Ⓧ (11) are cross-linked by hydrocarbon stapling

Bio-Activity Profile

Function

Anticancer Antimicrobial Antibacterial

PaperCromm PM, Spiegel J, Küchler P, Dietrich L, Kriegesmann J, Wendt M, Goody RS, Waldmann H, Grossmann TN. Protease-Resistant and Cell-Permeable Double-Stapled Peptides Targeting the Rab8a GTPase. ACS Chem Biol. 2016 Aug 19;11(8):2375-92. PMID27336832 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/27336832/