Peptide Database

Peptide NamePi-theraphotoxin-Pc1a

Function Ontology

Venom / Toxin ▸ General toxin ▸ Toxin

Venom / Toxin ▸ Toxin

Standard StatusStandard

Sequence Length40 amino acids

Chemical FormulaC200H318N62O57S6

DescriptionStandard

        EDCIPKWKGCVNRHGDCCEGLECWKRRRSFEVCVPKTPKT
    

Molecular Weight4695.44 Da

Isoelectric Point (pI)8.66

Net Charge (pH 7.0)2.87

Net Charge (pH 7.4) 2.55

Charge Density (pH 7.0) 0.0718

GRAVY Index-0.91

Hydrophobic Moment 0.51

Boman Index-0.30

Instability Index79.67

Aliphatic Index 41.25

Aromaticity 0.0750

Extinction Coeff. Reduced 11000.00

Extinction Coeff. Oxidized 11375.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1937.39

LogP -19.25

H-bond Donors 74.0

H-bond Acceptors 67.0

Rotatable Bonds 154.0

Heavy Atoms 325.0

Ring Count 9.0

Amide Bonds 40.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0114403 VERIFIED: YES

Provenance & Taxonomy

OrganismPsalmopoeus cambridgei [Animal]

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Disulfide3-18; 10-23; 17-33

Bio-Activity Profile

Function

Toxin Venom ASIC1a inhibitor Ion-channel modulator

Targetacid-sensing ion channel 1a (ASIC1a), Gallus gallus

MethodX-ray diffraction (PcTx1-ASIC1a complex), 2.80 Å

RECORD: Rec_0263395 VERIFIED: YES

Provenance & Taxonomy

OrganismPsalmopoeus cambridgei [Animal]

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Toxin ASIC1a inhibitor Ion-channel modulator

Targethuman acid-sensing ion channel 1a (ASIC1a)

Activity0.9 nM

MethodIC50