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MYP_029862
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Basic Information
HCC-1(9-74)
Immunology ▸ Chemokine signaling ▸ Chemokine-like peptide
Immunology ▸ Immune modulation ▸ Cytokine modulation
Regulatory peptide ▸ Cell signaling / Growth factor signaling ▸ Growth factor activity
Standard
66 amino acids
C344H520N92O104S6
Standard
Sequence
GPYHPSECCFTYTTYKIPRQRIMDYYETNSQCSKPGIVFITKRGHSVCTNPSDKWVQDYIKDMKEN
Physicochemical Analysis
7800.75 Da
8.41
1.90
1.51
0.0287
-0.92
0.65
-0.15
26.91
42.73
0.1364
14440.00
14690.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
3189.39
-32.68
114.0
114.0
250.0
546.0
17.0
71.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0221960 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
intercrine beta (chemokine CC) family
9606; 0
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
8-32; 9-48
Bio-Activity Profile
Chemokine CCR agonist Chemotactic Anti-HIV Cytokine
X-ray diffraction (CCL14/HCC-1[9-74] structure), 1.82 Å
PaperSolution and crystal structures of CCL14 reveal a unique chemokine architecture PMID17691823
RECORD: Rec_0433186 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
CC chemokine
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
8-32; 9-48
Bio-Activity Profile
Chemokine CCR agonist Chemotactic Anti-HIV
human CCR1
0.023±0.007 nM
Ki
PaperNatural proteolytic processing of hemofiltrate CC chemokine 1 generates a potent CCR1 and CCR5 agonist with anti-HIV properties PMID11085751
RECORD: Rec_0433187 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
CC chemokine
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
8-32; 9-48
Bio-Activity Profile
Chemokine CCR agonist Chemotactic Anti-HIV
human CCR1
2.8±0.8 nM
EC50 (aequorin functional assay)
PaperNatural proteolytic processing of hemofiltrate CC chemokine 1 generates a potent CCR1 and CCR5 agonist with anti-HIV properties PMID11085751
RECORD: Rec_0433188 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
CC chemokine
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
8-32; 9-48
Bio-Activity Profile
Chemokine CCR agonist Chemotactic Anti-HIV
human CCR3
2.7±0.8 nM
Ki
PaperNatural proteolytic processing of hemofiltrate CC chemokine 1 generates a potent CCR1 and CCR5 agonist with anti-HIV properties PMID11085751
RECORD: Rec_0433189 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
CC chemokine
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
8-32; 9-48
Bio-Activity Profile
Chemokine CCR agonist Chemotactic Anti-HIV
human CCR3
78±14 nM
EC50 (aequorin functional assay)
PaperNatural proteolytic processing of hemofiltrate CC chemokine 1 generates a potent CCR1 and CCR5 agonist with anti-HIV properties PMID11085751
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