Peptide Database

Peptide NameProopiomelanocortin-A derived peptide 1

Function Ontology

Hormonal / Endocrine ▸ Hormone peptide

Neurological / Signaling ▸ Neuromodulation

Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide

Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide precursor

Standard StatusStandard

Sequence Length10 amino acids

Chemical FormulaC57H85N17O15

DescriptionStandard

        ALGERKYHFQ
    

Molecular Weight1248.39 Da

Isoelectric Point (pI)8.64

Net Charge (pH 7.0)0.88

Net Charge (pH 7.4) 0.64

Charge Density (pH 7.0) 0.0884

GRAVY Index-1.19

Hydrophobic Moment 0.06

Boman Index-0.24

Instability Index3.43

Aliphatic Index 49.00

Aromaticity 0.2000

Extinction Coeff. Reduced 1490.00

Extinction Coeff. Oxidized 1490.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 542.44

LogP -3.86

H-bond Donors 19.0

H-bond Acceptors 17.0

Rotatable Bonds 41.0

Heavy Atoms 89.0

Ring Count 3.0

Amide Bonds 10.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0193850 VERIFIED: NO

Provenance & Taxonomy

OrganismOncorhynchus mykiss,Salmo gairdneri irideus [Animal]

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

C-TermAmidation

Bio-Activity Profile

Function

-

RECORD: Rec_0304414 VERIFIED: YES

Provenance & Taxonomy

OrganismOncorhynchus mykiss [Animal]

FamilyPOMC

Tax ID8022

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

C-TermAmidation

Bio-Activity Profile

Function

Hormone precursor Neuropeptide precursor

RECORD: Rec_0315758 VERIFIED: YES

Provenance & Taxonomy

OrganismOncorhynchus mykiss [Animal]

FamilyC-terminal peptide

Tax ID8022

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

C-TermAmidation

Bio-Activity Profile

Function

Hormone Endocrine Neuropeptide Neuromodulator

Half-LifeMammalian: 4.4 hour; Yeast: >20 hour; E. coli: >10 hour

RECORD: Rec_0373624 VERIFIED: YES

Provenance & Taxonomy

Organismnot reported [other]

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Neuropeptide

Paper数据库级溯源文献：Wang Y, Wang M, Yin S, et al. NeuroPep: a comprehensive resource of neuropeptides. Database (Oxford). 2015:bav038. PMID 25931458; Bin Y, Zhang W, Tang W, et al. Prediction of Neuropeptides from Sequence Information Using Ensemble Classifier and Hybrid Features. J Proteome Res. 2020;19(9):3732-3740. PMID 32786686. PMID25931458;32786686 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25931458/