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MYP_029785
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Basic Information
Trialysin (1-29)
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antiparasitic ▸ Antiprotozoal
Antiparasitic ▸ Antiprotozoal ▸ Anti-Trypanosoma
Antiparasitic ▸ General antiparasitic ▸ Antiparasitic
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytolysis / cell lysis ▸ Cytolytic activity
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
27 amino acids
C145H253N37O32
Standard
Sequence
FKIKPGKVLDKFGKIVGKVLKQLKKVS
Physicochemical Analysis
3026.79 Da
10.54
7.75
7.54
0.2871
-0.11
0.77
-0.05
-34.00
115.19
0.0741
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1145.93
-5.36
39.0
40.0
112.0
214.0
3.0
27.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0024535 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antiparasitic Antiprotozoal
Trypanosoma cruzi Y
4 μg/mL
LC50
PMID16460023 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16460023/
RECORD: Rec_0095343 VERIFIED: YES
Provenance & Taxonomy
Triatoma infestans [Animal]
Trialysin
30076
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Cytolytic Antiparasitic Anti-Trypanosoma cruzi
Trypanosoma cruzi
1.3 μM
LC50; Microscopy (Surviving parasites counted by Neubauer hemocytometer)
PMID16460023 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16460023/
RECORD: Rec_0174744 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide; DSSP H 18.5%, E 7.4%, T 40.7%, C 33.3% [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antiparasitic Toxic Antimicrobial Cytotoxic Antitrypanosomal
PaperParaPep: a web resource for experimentally validated antiparasitic peptide sequences and their structures PMID24923818 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24923818/
RECORD: Rec_0189146 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Hemolytic
human erythrocytes
900 μg/mL
Hemolysis
PMID16460023 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16460023/
RECORD: Rec_0286683 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Toxic Hemolytic
PaperHemolytik: a database of experimentally determined hemolytic and non-hemolytic peptides PMID24174543 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24174543/
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