Peptide Database

Peptide NameSLAY-screened peptide P4597

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length20 amino acids

Chemical FormulaC123H178N32O21S4

DescriptionStandard

        ALVWHHCFLPFLIMRKWHMC
    

Molecular Weight2569.19 Da

Isoelectric Point (pI)8.96

Net Charge (pH 7.0)2.04

Net Charge (pH 7.4) 1.67

Charge Density (pH 7.0) 0.1018

GRAVY Index0.74

Hydrophobic Moment 0.30

Boman Index0.35

Instability Index48.67

Aliphatic Index 97.50

Aromaticity 0.2000

Extinction Coeff. Reduced 11000.00

Extinction Coeff. Oxidized 11125.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 812.97

LogP 1.56

H-bond Donors 31.0

H-bond Acceptors 30.0

Rotatable Bonds 77.0

Heavy Atoms 180.0

Ring Count 10.0

Amide Bonds 19.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0282730 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/