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MYP_029565
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Basic Information
Cycloviolacin-Y1 (Plants)
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antiparasitic ▸ Anthelminthic
Antiparasitic ▸ Anthelminthic ▸ Nematicidal activity
Antiviral
Antiviral ▸ Anti-HIV
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxic
Venom / Toxin ▸ General toxin ▸ Toxicity
Standard
33 amino acids
C145H203N35O49S6
Standard
Sequence
GGTIFDCGETCFLGTCYTPGCSCGNYGFCYGTN
Physicochemical Analysis
3412.76 Da
4.05
-2.30
-2.60
-0.0696
0.14
0.36
0.27
2.21
23.64
0.1818
4470.00
4845.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1328.58
-18.30
52.0
53.0
101.0
235.0
7.0
34.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0266464 VERIFIED: YES
Provenance & Taxonomy
Viola yedoensis [Plant]
Cyclotide
Structure & Mods
head-to-tail cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
Cyclization
Cyclization
7-21; 11-23; 16-29
Bio-Activity Profile
Antimicrobial Antiviral
IC50>4
PaperPubMed PMID: 18081258 | Cyclotides as natural anti-HIV agents. Biopolymers. 2008;90(1):51-60. doi: 10.1002/bip.20886. PMID: 18008336. PMID18081258;18008336 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18081258/
RECORD: Rec_0284290 VERIFIED: YES
Provenance & Taxonomy
Viola yedoensis [Plant]
Cyclotide
Structure & Mods
Backbone-cyclized cyclotide scaffold with cystine-knot family annotation [Cyclic]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral
HIV
1.2 μM
EC50
PMID18081258 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18081258/
RECORD: Rec_0303135 VERIFIED: NO
Provenance & Taxonomy
Viola yedoensis [Plant]
Cyclotide
Structure & Mods
backbone-cyclized peptide [Cyclic]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antiviral Hemolytic
RECORD: Rec_0326217 VERIFIED: YES
Provenance & Taxonomy
Viola yedoensis [Plant]
Cyclotide
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
Cyclization (N termini to C termini)
Cyclization (N termini to C termini)
7-21, 11-23, 16-29
Disulfide bonds between Cys7 and Cys21; Cys11 and Cys23; Cys16 and Cys29.
Bio-Activity Profile
Antiviral Anti-HIV Entry inhibition
Anti-HIV activity
1.2 μM
EC50
Mammalian: 30 h; Yeast: >20 h; E. coli: >10 h
PaperAnti-HIV cyclotides from the Chinese medicinal herb Viola yedoensis. | Wang CK, Colgrave ML, Gustafson KR, Ireland DC, Goransson U, Craik DJ. | J Nat Prod. 2008 Jan;71(1):47-52. | DOI:10.1021/np070393g | PMID:18081258 PMID18081258 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18081258/
RECORD: Rec_0339360 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Toxic Antimicrobial Hemolytic Cytotoxic
PaperHemolytik: a database of experimentally determined hemolytic and non-hemolytic peptides PMID24174543 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24174543/
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