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MYP_029565
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Basic Information
Cycloviolacin-Y1 (Plants)
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antiparasitic ▸ Anthelminthic
Antiparasitic ▸ Anthelminthic ▸ Nematicidal activity
Antiviral
Antiviral ▸ Anti-HIV
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxic
Venom / Toxin ▸ General toxin ▸ Toxicity
Standard
33 amino acids
C145H203N35O49S6
Standard
Sequence
GGTIFDCGETCFLGTCYTPGCSCGNYGFCYGTN
Physicochemical Analysis
3412.76 Da
4.05
-2.30
-2.60
-0.0696
0.14
0.36
0.27
2.21
23.64
0.1818
4470.00
4845.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1328.58
-18.30
52.0
53.0
101.0
235.0
7.0
34.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0204109 VERIFIED: YES
Provenance & Taxonomy
Viola arvensis [Plant]
Cyclotide
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0213973 VERIFIED: YES
Provenance & Taxonomy
Viola yedoensis [Plant]
Cyclotide
Structure & Mods
head-to-tail cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
Cyclization
Cyclization
7-21; 11-23; 16-29
Bio-Activity Profile
Antimicrobial Antiviral Cytotoxic
PaperPubMed PMID: 18081258 | Cyclotides as natural anti-HIV agents. Biopolymers. 2008;90(1):51-60. doi: 10.1002/bip.20886. PMID: 18008336. PMID18081258;18008336 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18081258/
RECORD: Rec_0232024 VERIFIED: YES
Provenance & Taxonomy
Viola yedoensis [Plant]
Cyclotide
Structure & Mods
head-to-tail cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
Cyclization
Cyclization
7-21; 11-23; 16-29
Bio-Activity Profile
Antimicrobial Antiviral
NOTE:EC50 refers to the values for HIV-infected cell cultures
PaperPubMed PMID: 18081258 | Cyclotides as natural anti-HIV agents. Biopolymers. 2008;90(1):51-60. doi: 10.1002/bip.20886. PMID: 18008336. PMID18081258;18008336 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18081258/
RECORD: Rec_0235138 VERIFIED: YES
Provenance & Taxonomy
Viola yedoensis [Plant]
Cyclotide
Structure & Mods
head-to-tail cyclic peptide scaffold [Cyclic]
canonical L-amino-acid peptide [L]
Cysteine-rich scaffold consistent with multiple disulfide bonds in the annotated family
Bio-Activity Profile
Antiviral Nematocidal Anthelmintic Hemolytic Anti-HIV
Haemonchus contortus
PaperThe anthelmintic activity of the cyclotides: natural variants with enhanced activity | PubMed PMID 18081250 PMID18081250 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18081250/
RECORD: Rec_0256162 VERIFIED: YES
Provenance & Taxonomy
Viola yedoensis [Plant]
Cyclotide
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
Cyclization (N termini to C termini)
Cyclization (N termini to C termini)
7-21, 11-23, 16-29
Disulfide bonds between Cys7 and Cys21; Cys11 and Cys23; Cys16 and Cys29.
Bio-Activity Profile
Antiviral Anti-HIV Entry inhibition
HIV
1.21 μM
EC50
Mammalian: 30 h; Yeast: >20 h; E. coli: >10 h
PaperCyclotides as natural anti-HIV agents. | Ireland DC, Wang CK, Wilson JA, Gustafson KR, Craik DJ. | Biopolymers. 2008;90(1):51-60. | DOI:10.1002/bip.20886 | PMID:18008336 PMID18008336 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18008336/
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