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MYP_029565
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Basic Information
Cycloviolacin-Y1 (Plants)
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antiparasitic ▸ Anthelminthic
Antiparasitic ▸ Anthelminthic ▸ Nematicidal activity
Antiviral
Antiviral ▸ Anti-HIV
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxic
Venom / Toxin ▸ General toxin ▸ Toxicity
Standard
33 amino acids
C145H203N35O49S6
Standard
Sequence
GGTIFDCGETCFLGTCYTPGCSCGNYGFCYGTN
Physicochemical Analysis
3412.76 Da
4.05
-2.30
-2.60
-0.0696
0.14
0.36
0.27
2.21
23.64
0.1818
4470.00
4845.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1328.58
-18.30
52.0
53.0
101.0
235.0
7.0
34.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0084758 VERIFIED: YES
Provenance & Taxonomy
Viola yedoensis [Plant]
Cyclotide
Structure & Mods
head-to-tail cyclic peptide scaffold [Cyclic]
canonical L-amino-acid peptide [L]
Cysteine-rich scaffold consistent with multiple disulfide bonds in the annotated family
Bio-Activity Profile
Antiviral Nematocidal Anthelmintic Hemolytic Anti-HIV
Trichostrongylus colubriformis
PaperThe anthelmintic activity of the cyclotides: natural variants with enhanced activity | PubMed PMID 18081250 PMID18081250 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18081250/
RECORD: Rec_0102172 VERIFIED: YES
Provenance & Taxonomy
Insecta [Animal]
50557
Structure & Mods
cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
PMID16872274 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16872274/
RECORD: Rec_0111849 VERIFIED: YES
Provenance & Taxonomy
Viola yedoensis [Plant]
Cyclotide
Structure & Mods
head-to-tail cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
Cyclization
Cyclization
7-21; 11-23; 16-29
Bio-Activity Profile
Antimicrobial Antiviral
ers to the values for uninfected cell cultures
PaperPubMed PMID: 18081258 | Cyclotides as natural anti-HIV agents. Biopolymers. 2008;90(1):51-60. doi: 10.1002/bip.20886. PMID: 18008336. PMID18081258;18008336 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18081258/
RECORD: Rec_0122128 VERIFIED: YES
Provenance & Taxonomy
Viola odorata [Plant]
97441
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral Toxicity
>3.5 μM
TC50
PaperAnti-HIV cyclotides from the Chinese medicinal herb Viola yedoensis.
RECORD: Rec_0137110 VERIFIED: YES
Provenance & Taxonomy
Viola yedoensis [Plant]
Cyclotide
Structure & Mods
head-to-tail cyclic peptide scaffold [Cyclic]
canonical L-amino-acid peptide [L]
Cysteine-rich scaffold consistent with multiple disulfide bonds in the annotated family
Bio-Activity Profile
Antiviral Nematocidal Anthelmintic Hemolytic Anti-HIV
HIV
PaperThe anthelmintic activity of the cyclotides: natural variants with enhanced activity | PubMed PMID 18081250 PMID18081250 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18081250/
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