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MYP_029565
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Basic Information
Cycloviolacin-Y1 (Plants)
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antiparasitic ▸ Anthelminthic
Antiparasitic ▸ Anthelminthic ▸ Nematicidal activity
Antiviral
Antiviral ▸ Anti-HIV
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxic
Venom / Toxin ▸ General toxin ▸ Toxicity
Standard
33 amino acids
C145H203N35O49S6
Standard
Sequence
GGTIFDCGETCFLGTCYTPGCSCGNYGFCYGTN
Physicochemical Analysis
3412.76 Da
4.05
-2.30
-2.60
-0.0696
0.14
0.36
0.27
2.21
23.64
0.1818
4470.00
4845.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1328.58
-18.30
52.0
53.0
101.0
235.0
7.0
34.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0009074 VERIFIED: YES
Provenance & Taxonomy
Viola yedoensis [Plant]
Cyclotide
Structure & Mods
head-to-tail cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
Cyclization
Cyclization
7-21; 11-23; 16-29
Bio-Activity Profile
Antimicrobial Antiviral Hemolytic
PaperPubMed PMID: 18081258 | Cyclotides as natural anti-HIV agents. Biopolymers. 2008;90(1):51-60. doi: 10.1002/bip.20886. PMID: 18008336. PMID18081258;18008336 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18081258/
RECORD: Rec_0014997 VERIFIED: YES
Provenance & Taxonomy
Viola yedoensis [Plant]
Cyclotide
Structure & Mods
Backbone-cyclized cyclotide scaffold with cystine-knot family annotation [Cyclic]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Hemolytic
Human type A erythrocytes
4.5 μM
IC50
PMID18081258 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18081258/
RECORD: Rec_0031532 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Cyclotide
Structure & Mods
cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Anti-HIV
Human erythrocytes
Hemolysis
Paperhttps://pubmed.ncbi.nlm.nih.gov/18081258/ PMID18081258 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18081258/
RECORD: Rec_0053670 VERIFIED: YES
Provenance & Taxonomy
Viola yedoensis [Plant]
Cyclotide
Structure & Mods
head-to-tail cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
Cyclization
Cyclization
7-21; 11-23; 16-29
Bio-Activity Profile
Antimicrobial Antiviral Cytotoxic Anticancer
CEM-SS cells
4.47 μM
IC50
PaperPubMed PMID: 18081258 | Cyclotides as natural anti-HIV agents. Biopolymers. 2008;90(1):51-60. doi: 10.1002/bip.20886. PMID: 18008336. PMID18081258;18008336 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18081258/
RECORD: Rec_0061467 VERIFIED: YES
Provenance & Taxonomy
Viola yedoensis [Plant]
Cyclotide
Structure & Mods
head-to-tail cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
Cyclization
Cyclization
7-21; 11-23; 16-29
Bio-Activity Profile
Antimicrobial Antiviral
Anti-HIV activity:EC50=1
PaperPubMed PMID: 18081258 | Cyclotides as natural anti-HIV agents. Biopolymers. 2008;90(1):51-60. doi: 10.1002/bip.20886. PMID: 18008336. PMID18081258;18008336 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18081258/
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