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MYP_029555
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Basic Information
Huwentoxin-V
Venom / Toxin ▸ General toxin ▸ Toxin
Standard
35 amino acids
C176H243N49O55S6
Standard
Sequence
ECRWYLGGCSQDGDCCKHLQCHSNYEWCVWDGTFS
Physicochemical Analysis
4117.50 Da
4.80
-3.05
-3.41
-0.0870
-0.66
0.34
-0.03
62.14
30.57
0.1714
19480.00
19855.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1682.52
-17.71
65.0
60.0
128.0
286.0
11.0
37.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0344527 VERIFIED: YES
Provenance & Taxonomy
Selenocosmia huwena [Animal]
Structure & Mods
disulfide-constrained linear peptide [Linear]
canonical L-amino-acid peptide [L]
2-16; 9-21; 15-28
Bio-Activity Profile
Insecticidal Neurotoxin Toxin
locusts; Periplaneta americana
16±5 μg/g
ED50; intra-abdominal insect paralysis assay
PaperHuwentoxin-V, a novel insecticidal peptide toxin from the spider Selenocosmia huwena, and a natural mutant of the toxin: indicates the key amino acid residues related to the biological activity PMID12893056
RECORD: Rec_0433175 VERIFIED: YES
Provenance & Taxonomy
Ornithoctonus huwena [Animal]
Spider toxin
Structure & Mods
disulfide-constrained linear peptide [Linear]
canonical L-amino-acid peptide [L]
2-16; 9-21; 15-28
Bio-Activity Profile
Calcium channel inhibitor Insecticidal Neurotoxin Toxin
Periplaneta americana dorsal unpaired median neurons; high-voltage-activated calcium channels
≈219 nM
IC50; whole-cell patch-clamp
PaperInhibition of insect calcium channels by huwentoxin-V, a neurotoxin from Chinese tarantula Ornithoctonus huwena venom PMID18234186