Peptide Database

Peptide NameUnnamed

Function Ontology

Antimicrobial

Antiviral

Antiviral ▸ Anti-HIV ▸ Anti-HIV-1

Antiviral ▸ Antiviral mechanism ▸ Viral replication inhibition

Enzyme modulation ▸ Enzyme inhibition ▸ Integrase inhibition

Standard StatusStandard

Sequence Length6 amino acids

Chemical FormulaC38H50N10O7S

DescriptionStandard

        HCKFWA
    

Molecular Weight790.93 Da

Isoelectric Point (pI)8.23

Net Charge (pH 7.0)0.84

Net Charge (pH 7.4) 0.57

Charge Density (pH 7.0) 0.1394

GRAVY Index-0.15

Hydrophobic Moment 0.31

Boman Index0.17

Instability Index-16.72

Aliphatic Index 16.67

Aromaticity 0.3333

Extinction Coeff. Reduced 5500.00

Extinction Coeff. Oxidized 5500.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 279.31

LogP -0.17

H-bond Donors 11.0

H-bond Acceptors 10.0

Rotatable Bonds 22.0

Heavy Atoms 56.0

Ring Count 4.0

Amide Bonds 5.0

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.

2D CHEMICAL STRUCTURE

Drag to move

Drag to move. Use the buttons to zoom.

RECORD: Rec_0423943 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyProtein-derived synthetic peptide

Tax ID32630

Structure & Mods

Configsynthetic linear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermAmidation

Bio-Activity Profile

Function

Antiviral Anti-HIV-1 Replication inhibition

TargetHIV-1

Activity210 μM

MethodIC50

Half-LifeMammalian: 3.5 h; Yeast: 10 min; E. coli: >10 h

PaperIdentification of a hexapeptide inhibitor of the human immunodeficiency virus integrase protein by using a combinatorial chemical library. | Puras Lutzke RA, Eppens NA, Weber PA, Houghten RA, Plasterk RH. | Proc Natl Acad Sci U S A. 1995 Dec 5;92(25):11456-60. | DOI:10.1073/pnas.92.25.11456 | PMID:8524782 PMID8524782 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/8524782/

FIRST PREV 1 2

Showing 1 records on this page Ã‚Â· Page 2 of 2