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MYP_029341
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Basic Information
A4
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Standard
9 amino acids
C54H83N23O10S2
Standard
Sequence
CRRWGWRRC
Physicochemical Analysis
1278.52 Da
11.53
3.74
3.51
0.4156
-1.69
0.32
-0.83
202.01
0.00
0.2222
11000.00
11125.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
575.30
-4.73
26.0
16.0
39.0
89.0
4.0
8.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0190719 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Cathelicidin
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Cutibacterium acnes KCTC3314
27.1 μg/mL
MEC (ultrasensitive radial diffusion assay / URDA)
PMID34436290 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/34436290/
RECORD: Rec_0265470 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Cathelicidin
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Candida albicans KCTC7965
17.2 μg/mL
MEC (ultrasensitive radial diffusion assay / URDA)
PMID34436290 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/34436290/
RECORD: Rec_0383897 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Cathelicidin
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Bacillus subtilis KCTC1021
2.5 μg/mL
MEC (ultrasensitive radial diffusion assay / URDA)
PMID34436290 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/34436290/
RECORD: Rec_0433162 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
AOD-derived analog
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
C-terminal amidation
Bio-Activity Profile
Non-hemolytic Cytocompatible
human erythrocytes (blood type B)
Hemolysis assay (3.13–100 μg/mL; no significant hemolysis)
PaperAntimicrobial Activity and Action Mechanisms of Arg-Rich Short Analog Peptides Designed from the C-Terminal Loop Region of American Oyster Defensin (AOD) PMID34436290
RECORD: Rec_0433163 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
AOD-derived analog
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
C-terminal amidation
Bio-Activity Profile
Cytocompatible Low cytotoxicity
human dermal fibroblasts (HDF)
MTT cell viability assay (6.25–100 μg/mL; high viability at 50–100 μg/mL)
PaperAntimicrobial Activity and Action Mechanisms of Arg-Rich Short Analog Peptides Designed from the C-Terminal Loop Region of American Oyster Defensin (AOD) PMID34436290
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