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MYP_029084
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Basic Information
DFT561d
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Standard
13 amino acids
C67H125N15O15
Standard
Sequence
GLKLLLSLGLKLL
Physicochemical Analysis
1380.80 Da
10.00
1.76
1.55
0.1352
1.62
0.44
0.48
-16.89
240.00
0.0000
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
484.79
0.10
17.0
17.0
50.0
97.0
0.0
12.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0291480 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
all-D amino-acid peptide [D]
all-D residues
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Escherichia coli ampC E416-7
50 μM
MIC
PaperLow cationicity is important for systemic in vivo efficacy of database-derived peptides against drug-resistant Gram-positive pathogens PMID31209048 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/31209048/
RECORD: Rec_0296551 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
all-D amino-acid peptide [D]
all-D residues
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Escherichia coli E423-17
50 μM
MIC
PaperLow cationicity is important for systemic in vivo efficacy of database-derived peptides against drug-resistant Gram-positive pathogens PMID31209048 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/31209048/
RECORD: Rec_0300274 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Escherichia coli E423-17
50 μM
MIC
PaperLow cationicity is important for systemic in vivo efficacy of database-derived peptides against drug-resistant Gram-positive pathogens PMID31209048 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/31209048/
RECORD: Rec_0339825 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
Amidation
APD analysis reveals that this sequence is poorly similar (92.31%) to DFT503 . L: 62%. Chemical modification: C-terminal amidation
Bio-Activity Profile
Antimicrobial
E-coli ATCC 25922
>25 μM
MIC
PaperLow cationicity is important for systemic in vivo efficacy of database-derived peptides against drug-resistant Gram-positive pathogens PMID31209048 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/31209048/
RECORD: Rec_0373453 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Enterococcus faecium V286-17
3.1-6.25 μM
MIC
PaperLow cationicity is important for systemic in vivo efficacy of database-derived peptides against drug-resistant Gram-positive pathogens PMID31209048 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/31209048/
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