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MYP_029084
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Basic Information
DFT561d
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Standard
13 amino acids
C67H125N15O15
Standard
Sequence
GLKLLLSLGLKLL
Physicochemical Analysis
1380.80 Da
10.00
1.76
1.55
0.1352
1.62
0.44
0.48
-16.89
240.00
0.0000
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
484.79
0.10
17.0
17.0
50.0
97.0
0.0
12.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0120294 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
all-D amino-acid peptide [D]
all-D residues
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Escherichia coli ATCC 25922
25 μM
MIC
PaperLow cationicity is important for systemic in vivo efficacy of database-derived peptides against drug-resistant Gram-positive pathogens PMID31209048 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/31209048/
RECORD: Rec_0135998 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
all-D amino-acid peptide [D]
all-D residues
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Pseudomonas aeruginosa E411-17
50 μM
MIC
PaperLow cationicity is important for systemic in vivo efficacy of database-derived peptides against drug-resistant Gram-positive pathogens PMID31209048 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/31209048/
RECORD: Rec_0162363 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
all-D amino-acid peptide [D]
all-D residues
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Klebsiella pneumoniae
25 μM
MIC
PaperLow cationicity is important for systemic in vivo efficacy of database-derived peptides against drug-resistant Gram-positive pathogens PMID31209048 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/31209048/
RECORD: Rec_0166214 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
Amidation
APD analysis reveals that this sequence is poorly similar (92.31%) to DFT503 . L: 62%. Chemical modification: C-terminal amidation
Bio-Activity Profile
Antimicrobial
E. faecium V286-17
3.1-6.25 μM
MIC
PaperLow cationicity is important for systemic in vivo efficacy of database-derived peptides against drug-resistant Gram-positive pathogens PMID31209048 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/31209048/
RECORD: Rec_0179636 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
Amidation
APD analysis reveals that this sequence is poorly similar (92.31%) to DFT503 . L: 62%. Chemical modification: C-terminal amidation
Bio-Activity Profile
Antimicrobial
Staphylococcus aureus USA300 or M838-17
1.56-3.1 μM
MIC
PaperLow cationicity is important for systemic in vivo efficacy of database-derived peptides against drug-resistant Gram-positive pathogens PMID31209048 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/31209048/
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