Peptide Database

Peptide NameDefensin-2

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Standard StatusStandard

Sequence Length97 amino acids

Chemical FormulaC460H730N136O133S10

DescriptionStandard

        MKFFSLFPVIVVVVACLTMRANAAPSAGNEVDHHPDYVDGVEALRQLEPELHGRYKRATCDLLSMWNVNHSACAAHCLLLGKSGGRCNDDAVCVCRK
    

Molecular Weight10614.20 Da

Isoelectric Point (pI)6.93

Net Charge (pH 7.0)-0.12

Net Charge (pH 7.4) -0.71

Charge Density (pH 7.0) -0.0012

GRAVY Index0.08

Hydrophobic Moment 0.55

Boman Index0.06

Instability Index35.43

Aliphatic Index 88.45

Aromaticity 0.0619

Extinction Coeff. Reduced 8480.00

Extinction Coeff. Oxidized 8855.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 4270.04

LogP -42.59

H-bond Donors 154.0

H-bond Acceptors 148.0

Rotatable Bonds 344.0

Heavy Atoms 739.0

Ring Count 16.0

Amide Bonds 102.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0049031 VERIFIED: YES

Provenance & Taxonomy

OrganismStomoxys calcitrans [Animal]

FamilyDefensin

Tax ID35570

Structure & Mods

Configdisulfide-constrained cyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

Disulfidedisulfide bond; sites not specified

Bio-Activity Profile

Function

Antimicrobial Defensin Anti-Gram-negative Non-hemolytic

TargetGram-negative bacteria