Peptide Database

Peptide NameSLAY-screened peptide P181

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length20 amino acids

Chemical FormulaC113H154N26O31

DescriptionStandard

        PAEWSTVVGNFTYHFNYNLL
    

Molecular Weight2372.59 Da

Isoelectric Point (pI)5.25

Net Charge (pH 7.0)-0.95

Net Charge (pH 7.4) -1.07

Charge Density (pH 7.0) -0.0477

GRAVY Index-0.07

Hydrophobic Moment 0.34

Boman Index0.27

Instability Index-3.40

Aliphatic Index 73.00

Aromaticity 0.2500

Extinction Coeff. Reduced 8480.00

Extinction Coeff. Oxidized 8480.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 914.42

LogP -6.59

H-bond Donors 32.0

H-bond Acceptors 31.0

Rotatable Bonds 69.0

Heavy Atoms 170.0

Ring Count 8.0

Amide Bonds 22.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0410135 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/