Peptide Database

Peptide NameSLAY-screened peptide P4715

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length20 amino acids

Chemical FormulaC86H145N31O31S

DescriptionStandard

        AAGTRTNPVMDKTTRDAAHQ
    

Molecular Weight2141.33 Da

Isoelectric Point (pI)8.80

Net Charge (pH 7.0)0.88

Net Charge (pH 7.4) 0.64

Charge Density (pH 7.0) 0.0442

GRAVY Index-1.08

Hydrophobic Moment 0.52

Boman Index-0.29

Instability Index-2.56

Aliphatic Index 34.50

Aromaticity 0.0000

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1027.63

LogP -15.53

H-bond Donors 36.0

H-bond Acceptors 34.0

Rotatable Bonds 69.0

Heavy Atoms 149.0

Ring Count 2.0

Amide Bonds 21.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0221855 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/