Peptide Database

Peptide NameDefensin alpha-related sequence 1 (Protein Defa-rs1)

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive ▸ Anti-Staphylococcus aureus

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length87 amino acids

Chemical FormulaC407H681N121O140S6

DescriptionStandard

        MKTLILLSALVLLALQVQADPIQEAEEETKTEEQPADEDQDVSVSFEGPEASAVQDLRVRRTLQCSCRRVCRNTCSCIRLSRSTYAS
    

Molecular Weight9701.88 Da

Isoelectric Point (pI)4.73

Net Charge (pH 7.0)-4.52

Net Charge (pH 7.4) -4.83

Charge Density (pH 7.0) -0.0520

GRAVY Index-0.30

Hydrophobic Moment 0.79

Boman Index-0.13

Instability Index80.16

Aliphatic Index 90.80

Aromaticity 0.0230

Extinction Coeff. Reduced 1490.00

Extinction Coeff. Oxidized 1740.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 4277.39

LogP -51.34

H-bond Donors 154.0

H-bond Acceptors 142.0

Rotatable Bonds 330.0

Heavy Atoms 674.0

Ring Count 5.0

Amide Bonds 94.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0277399 VERIFIED: YES

Provenance & Taxonomy

OrganismRattus norvegicus [Animal]

FamilyAlpha-defensin; Defensin

Tax ID10116

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antibiotic Defensin Anti-MRSA Anti-Gram-negative Anti-Gram-positive Cytotoxic Non-hemolytic

TargetEscherichia coli (Gram-negative)

RECORD: Rec_0408606 VERIFIED: YES