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MYP_028973
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Basic Information
Defensin alpha-related sequence 1 (Protein Defa-rs1)
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive ▸ Anti-Staphylococcus aureus
Antimicrobial ▸ Antibiotic activity
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
87 amino acids
C407H681N121O140S6
Standard
Sequence
MKTLILLSALVLLALQVQADPIQEAEEETKTEEQPADEDQDVSVSFEGPEASAVQDLRVRRTLQCSCRRVCRNTCSCIRLSRSTYAS
Physicochemical Analysis
9701.88 Da
4.73
-4.52
-4.83
-0.0520
-0.30
0.79
-0.13
80.16
90.80
0.0230
1490.00
1740.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
4277.39
-51.34
154.0
142.0
330.0
674.0
5.0
94.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0033839 VERIFIED: YES
Provenance & Taxonomy
Rattus norvegicus [Animal]
Defensin
10116
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
PaperPubMed PMID: 10456937 PMID10456937 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/10456937/
RECORD: Rec_0036087 VERIFIED: YES
Provenance & Taxonomy
Rattus norvegicus [Animal]
Alpha-defensin; Defensin
10116
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibiotic Defensin Anti-MRSA Anti-Gram-negative Anti-Gram-positive Cytotoxic Non-hemolytic
Staphylococcus aureus (Gram-positive)
PMID15494476;15057822;23380721;28345637 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15494476/
RECORD: Rec_0075724 VERIFIED: NO
Provenance & Taxonomy
Ranitomeya imitator [Animal]
111125
Structure & Mods
gene-encoded linear polypeptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Defensin Non-hemolytic Non-ribosomal
Evidence URLhttps://www.uniprot.org/uniprotkb/A0A822IG14/entry
RECORD: Rec_0110975 VERIFIED: YES
Provenance & Taxonomy
Rattus norvegicus [Animal]
Alpha-defensin; Defensin
10116
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibiotic Defensin Anti-MRSA Anti-Gram-negative Anti-Gram-positive Cytotoxic Non-hemolytic
S. typhimurium
PMID15494476;15057822;23380721;28345637 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15494476/
RECORD: Rec_0228364 VERIFIED: YES
Provenance & Taxonomy
Rattus norvegicus [Animal]
Alpha-defensin; Defensin
10116
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibiotic Defensin Anti-MRSA Anti-Gram-negative Anti-Gram-positive Cytotoxic Non-hemolytic
K. pneumoniae (Gram-negative)
PMID15494476;15057822;23380721;28345637 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15494476/
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