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MYP_028944
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Basic Information
Frenatin 2.2S
Anticancer
Anticancer ▸ Apoptosis induction
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Immunology ▸ Immune modulation ▸ Immunomodulatory activity
Immunology ▸ Inflammation modulation ▸ Anti-inflammatory
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
16 amino acids
C71H125N19O19
Standard
Sequence
GLVGTLLGHIGKAILS
Physicochemical Analysis
1548.87 Da
8.76
0.85
0.59
0.0529
1.25
0.50
0.53
32.96
170.62
0.0000
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
594.98
-4.38
21.0
21.0
52.0
109.0
1.0
15.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0172260 VERIFIED: YES
Provenance & Taxonomy
Sphaenorhynchus lacteus [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Antimicrobial Pro-apoptotic Anticancer Antibacterial Anti-Gram-positive
Staphylococcus aureus
8 μM
MIC
RECORD: Rec_0197191 VERIFIED: YES
Provenance & Taxonomy
Sphaenorhynchus lacteus [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Antimicrobial Antifungal Anticancer Immunomodulatory
Showed a poor hemolysis of human erythrocytes
>160 μM
LC50
PaperA family of antimicrobial and immunomodulatory peptides related to the frenatins from skin secretions of the Orinoco lime frog Sphaenorhynchus lacteus (Hylidae).
RECORD: Rec_0227211 VERIFIED: YES
Provenance & Taxonomy
Sphaenorhynchus lacteus [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Antimicrobial Antifungal Anticancer Immunomodulatory
lung adenocarcinoma A549 cells
65 μM
LC50
PaperA family of antimicrobial and immunomodulatory peptides related to the frenatins from skin secretions of the Orinoco lime frog Sphaenorhynchus lacteus (Hylidae).
RECORD: Rec_0234777 VERIFIED: YES
Provenance & Taxonomy
Sphaenorhynchus lacteus [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-negative
Pseudomonas syringae pv. Actinidiae
50 μM
MIC
PMID30508634 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30508634/
RECORD: Rec_0266204 VERIFIED: YES
Provenance & Taxonomy
Sphaenorhynchus lacteus [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-negative
Xanthomonas fragariae
25-50 μM
MIC
PMID30508634 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30508634/
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