Peptide Database

Peptide NameSLAY-screened peptide P3000

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length21 amino acids

Chemical FormulaC102H171N33O34

DescriptionStandard

        ENHIEIHLVDRSRSASLLSIN
    

Molecular Weight2403.65 Da

Isoelectric Point (pI)6.02

Net Charge (pH 7.0)-0.98

Net Charge (pH 7.4) -1.26

Charge Density (pH 7.0) -0.0469

GRAVY Index-0.25

Hydrophobic Moment 0.27

Boman Index-0.07

Instability Index106.69

Aliphatic Index 130.00

Aromaticity 0.0000

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1105.48

LogP -12.57

H-bond Donors 39.0

H-bond Acceptors 35.0

Rotatable Bonds 82.0

Heavy Atoms 169.0

Ring Count 2.0

Amide Bonds 22.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0160228 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/