Peptide Database

Peptide NameSLAY-screened peptide P5853

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length18 amino acids

Chemical FormulaC114H161N27O24

DescriptionStandard

        HLLGYYRRFASYLLQFFV
    

Molecular Weight2293.66 Da

Isoelectric Point (pI)9.70

Net Charge (pH 7.0)1.84

Net Charge (pH 7.4) 1.59

Charge Density (pH 7.0) 0.1025

GRAVY Index0.49

Hydrophobic Moment 0.70

Boman Index0.24

Instability Index47.93

Aliphatic Index 108.33

Aromaticity 0.3333

Extinction Coeff. Reduced 4470.00

Extinction Coeff. Oxidized 4470.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 834.51

LogP -1.55

H-bond Donors 31.0

H-bond Acceptors 27.0

Rotatable Bonds 70.0

Heavy Atoms 165.0

Ring Count 7.0

Amide Bonds 18.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0294884 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/