Peptide Database

Peptide NameDermaseptin-H3

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive

Antimicrobial ▸ Antibiotic activity

Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Defense peptide

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Standard StatusStandard

Sequence Length69 amino acids

Chemical FormulaC334H542N88O109S4

DescriptionStandard

        MAFLKKSLFLVLFLGMVSLSICEEEKRENEDEEKQEDDEQSEMKRGLWSTIKNVAAAAGKAALGALGEQ
    

Molecular Weight7662.66 Da

Isoelectric Point (pI)4.64

Net Charge (pH 7.0)-5.48

Net Charge (pH 7.4) -5.74

Charge Density (pH 7.0) -0.0795

GRAVY Index-0.34

Hydrophobic Moment 0.64

Boman Index-0.03

Instability Index58.00

Aliphatic Index 86.38

Aromaticity 0.0580

Extinction Coeff. Reduced 5500.00

Extinction Coeff. Oxidized 5500.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 3222.88

LogP -29.95

H-bond Donors 110.0

H-bond Acceptors 108.0

Rotatable Bonds 274.0

Heavy Atoms 535.0

Ring Count 5.0

Amide Bonds 73.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0401012 VERIFIED: NO

Provenance & Taxonomy

OrganismPithecopus azureus [Animal]

FamilyDermaseptin

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Amphibian defense peptide Antibiotic Antimicrobial Anti-Gram-negative Anti-Gram-positive Non-hemolytic Non-ribosomal

TargetGram-negative bacteria; Gram-positive bacteria

MethodQualitative functional evidence