Peptide Database

Peptide NameBactericidal permeability-increasing protein

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length483 amino acids

Chemical FormulaC2451H3909N635O672S21

DescriptionStandard

        MARGLDNVLRQALLVVLAAVGTAMITATNPGAVARISQKGLDYACQQGMAVLQKELERIKIPDYAAKFKIKHLGKGHYNFYSMDIYDFRLPSSKIILVPTVGLKLSINNSSVRMSGKWKAQKSIVQTSGNFDLNIDGVSIFADLKLGSDPVLGKPTITCSGCDNTINSVRVHISGSKLGWLIQLFHKRIESSIRDIVNKEICKVMNNSVSSILQPYFQKLPVKSKIDGVAGIDFRLVKPPIITTEYLEIQLKGEFFRISNPYPPPYTPPAMEFPAVHNRMLYVGLSEYFFNTAGLVYQEAGILKLMLKDKMIPKEFGFRLTTTFFGTFLPQVAKSFPDMFINLAISVSAPPHVSMQPSGLVLTPILDVEAFAVLPNTSLAPLFLISTSAKASLEISATCNRLSGKLKLEGLLLELRHSNIYPLPVESLQAIMDYVMPTLVLPKINQRLQKGFRLPMPDRVHLYNLMLQSQHNFLLFSADVHHD
    

Molecular Weight53697.47 Da

Isoelectric Point (pI)9.44

Net Charge (pH 7.0)15.43

Net Charge (pH 7.4) 14.47

Charge Density (pH 7.0) 0.0320

GRAVY Index0.12

Hydrophobic Moment 0.84

Boman Index0.13

Instability Index37.85

Aliphatic Index 104.95

Aromaticity 0.0870

Extinction Coeff. Reduced 33350.00

Extinction Coeff. Oxidized 33600.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0149046 VERIFIED: NO

Provenance & Taxonomy

OrganismOtolemur garnettii [Animal]

FamilyBPI/LBP

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxic Non-hemolytic Non-ribosomal

TargetGram-negative bacteria

MethodQualitative functional evidence