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MYP_028832
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Basic Information
HYL-15
Anticancer
Toxicity / Safety ▸ Cytotoxicity
Venom / Toxin ▸ General toxin ▸ Cytotoxicity
Standard
16 amino acids
C69H126N18O19S2
Standard
Sequence
GIMSSLMKALAAAIAK
Physicochemical Analysis
1575.98 Da
10.00
1.76
1.55
0.1099
1.23
0.42
0.40
43.57
128.75
0.0000
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
592.32
-4.67
21.0
23.0
55.0
108.0
0.0
15.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0207823 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
HYL
32630
Structure & Mods
hydrocarbon-stapled side-chain cyclic peptide [Cyclic]
noncanonical stereochemical modification [Modified]
None
Amidation
Stapled: Ⓧ(9) and Ⓧ (13) are cross-linked by hydrocarbon stapling
Bio-Activity Profile
Cytotoxicity
HPDE6c7 Human Pancreatic Duct Epithelial Cell
3.45±0.20 μg/mL
IC50
PaperStructural modification and antitumor activity of antimicrobial peptide HYL. Chinese Chemical Letters. 2020;31(5):1288-1292. DOI:10.1016/j.cclet.2019.10.013. Evidence URLhttps://doi.org/10.1016/j.cclet.2019.10.013
RECORD: Rec_0324867 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
HYL
32630
Structure & Mods
hydrocarbon-stapled side-chain cyclic peptide [Cyclic]
noncanonical stereochemical modification [Modified]
None
Amidation
Stapled: Ⓧ(9) and Ⓧ (13) are cross-linked by hydrocarbon stapling
Bio-Activity Profile
Anticancer
HepG2
3.38±0.26 μM
IC50
PaperStructural modification and antitumor activity of antimicrobial peptide HYL. Chinese Chemical Letters. 2020;31(5):1288-1292. DOI:10.1016/j.cclet.2019.10.013. Evidence URLhttps://doi.org/10.1016/j.cclet.2019.10.013
RECORD: Rec_0417746 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
HYL
32630
Structure & Mods
hydrocarbon-stapled side-chain cyclic peptide [Cyclic]
noncanonical stereochemical modification [Modified]
None
Amidation
Stapled: Ⓧ(9) and Ⓧ (13) are cross-linked by hydrocarbon stapling
Bio-Activity Profile
Cytotoxicity
Normal Human Hepatic Cell (Lo-2)
2.91±0.07 μg/mL
IC50
PaperStructural modification and antitumor activity of antimicrobial peptide HYL. Chinese Chemical Letters. 2020;31(5):1288-1292. DOI:10.1016/j.cclet.2019.10.013. Evidence URLhttps://doi.org/10.1016/j.cclet.2019.10.013
RECORD: Rec_0425951 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
HYL
32630
Structure & Mods
hydrocarbon-stapled side-chain cyclic peptide [Cyclic]
noncanonical stereochemical modification [Modified]
None
Amidation
Stapled: Ⓧ(9) and Ⓧ (13) are cross-linked by hydrocarbon stapling
Bio-Activity Profile
Anticancer
A549
3.17±0.33 μM
IC50
PaperStructural modification and antitumor activity of antimicrobial peptide HYL. Chinese Chemical Letters. 2020;31(5):1288-1292. DOI:10.1016/j.cclet.2019.10.013. Evidence URLhttps://doi.org/10.1016/j.cclet.2019.10.013
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