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MYP_028832
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Basic Information
HYL-15
Anticancer
Toxicity / Safety ▸ Cytotoxicity
Venom / Toxin ▸ General toxin ▸ Cytotoxicity
Standard
16 amino acids
C69H126N18O19S2
Standard
Sequence
GIMSSLMKALAAAIAK
Physicochemical Analysis
1575.98 Da
10.00
1.76
1.55
0.1099
1.23
0.42
0.40
43.57
128.75
0.0000
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
592.32
-4.67
21.0
23.0
55.0
108.0
0.0
15.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0022605 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
HYL
32630
Structure & Mods
hydrocarbon-stapled side-chain cyclic peptide [Cyclic]
noncanonical stereochemical modification [Modified]
None
Amidation
Stapled: Ⓧ(9) and Ⓧ (13) are cross-linked by hydrocarbon stapling
Bio-Activity Profile
Anticancer
HCT116
2.52±0.42 μM
IC50
PaperStructural modification and antitumor activity of antimicrobial peptide HYL. Chinese Chemical Letters. 2020;31(5):1288-1292. DOI:10.1016/j.cclet.2019.10.013. Evidence URLhttps://doi.org/10.1016/j.cclet.2019.10.013
RECORD: Rec_0045307 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
HYL
32630
Structure & Mods
hydrocarbon-stapled side-chain cyclic peptide [Cyclic]
noncanonical stereochemical modification [Modified]
None
Amidation
Stapled: Ⓧ(9) and Ⓧ (13) are cross-linked by hydrocarbon stapling
Bio-Activity Profile
Cytotoxicity
Human Splenic Fibroblasts (HSF)
12.78±0.33 μg/mL
IC50
PaperStructural modification and antitumor activity of antimicrobial peptide HYL. Chinese Chemical Letters. 2020;31(5):1288-1292. DOI:10.1016/j.cclet.2019.10.013. Evidence URLhttps://doi.org/10.1016/j.cclet.2019.10.013
RECORD: Rec_0078195 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
HYL
32630
Structure & Mods
hydrocarbon-stapled side-chain cyclic peptide [Cyclic]
noncanonical stereochemical modification [Modified]
None
Amidation
Stapled: Ⓧ(9) and Ⓧ (13) are cross-linked by hydrocarbon stapling
Bio-Activity Profile
Cytotoxicity
NCM460
3.04±0.10 μg/mL
IC50
PaperStructural modification and antitumor activity of antimicrobial peptide HYL. Chinese Chemical Letters. 2020;31(5):1288-1292. DOI:10.1016/j.cclet.2019.10.013. Evidence URLhttps://doi.org/10.1016/j.cclet.2019.10.013
RECORD: Rec_0092087 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
HYL
32630
Structure & Mods
hydrocarbon-stapled side-chain cyclic peptide [Cyclic]
noncanonical stereochemical modification [Modified]
None
Amidation
Stapled: Ⓧ(9) and Ⓧ (13) are cross-linked by hydrocarbon stapling
Bio-Activity Profile
Cytotoxicity
CCD-19Lu
4.76±0.03 μg/mL
IC50
PaperStructural modification and antitumor activity of antimicrobial peptide HYL. Chinese Chemical Letters. 2020;31(5):1288-1292. DOI:10.1016/j.cclet.2019.10.013. Evidence URLhttps://doi.org/10.1016/j.cclet.2019.10.013
RECORD: Rec_0191162 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
HYL
32630
Structure & Mods
hydrocarbon-stapled side-chain cyclic peptide [Cyclic]
noncanonical stereochemical modification [Modified]
None
Amidation
Stapled: Ⓧ(9) and Ⓧ (13) are cross-linked by hydrocarbon stapling
Bio-Activity Profile
Cytotoxicity
Endometrial epithelial cells (HEEC)
2.66±0.34 μg/mL
IC50
PaperStructural modification and antitumor activity of antimicrobial peptide HYL. Chinese Chemical Letters. 2020;31(5):1288-1292. DOI:10.1016/j.cclet.2019.10.013. Evidence URLhttps://doi.org/10.1016/j.cclet.2019.10.013
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