Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length461 amino acids

Chemical FormulaC2329H3672N576O682S11

DescriptionStandard

        MEIIEQMVKERKIPDLKGNESLEFLKIDYVNYNFSNIKINAFSFPNTSLAFVPGVGIKVLTNHGTTNISTDWEVKSPLFQDTGGADLFLSGVYFTGVLILARNDFGQPTVKLQDCYAQVSHAQVSFSGELKVLYNSFAEPMEKPILRNLNEILCPIITSEVEALNANLSVLEVLTKIDNYTRLDYSLISSPEITENYLDLNLKGVFYPLENLTDPPFSPVPIVLPERSDSMLYIGLSKYFFKSVSFAYFTAGAFNVTLSTKEISSHLIPNSQGLGSMLSRLAEIYILSQPLMVRIMATEPPVISLLPGNFTLDIPASIIILTQAENSTAETIVSMDFVASTSVGLVILGQRLICSLSLNRFRLSLPESSRGSIEVLRFENILSSIIHFGVLPLANAKLQQGFPLPHPHKISFVNSDVEVLEDLLLISTNLKYETSLKQPPSFPGWADLNLISRQLSGKPAP
    

Molecular Weight51006.23 Da

Isoelectric Point (pI)5.09

Net Charge (pH 7.0)-11.94

Net Charge (pH 7.4) -12.62

Charge Density (pH 7.0) -0.0259

GRAVY Index0.17

Hydrophobic Moment 0.77

Boman Index0.17

Instability Index38.25

Aliphatic Index 109.72

Aromaticity 0.0911

Extinction Coeff. Reduced 31860.00

Extinction Coeff. Oxidized 31985.00

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Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0392393 VERIFIED: NO

Provenance & Taxonomy

OrganismEquus asinus asinus [Animal]

FamilyBPI

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin

TargetGram-negative bacteria

MethodQualitative functional evidence