Peptide Database

Peptide NameSLAY-screened peptide P5828

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length12 amino acids

Chemical FormulaC64H96N12O18S3

DescriptionStandard

        LTFPEMCPCLTY
    

Molecular Weight1417.71 Da

Isoelectric Point (pI)4.05

Net Charge (pH 7.0)-1.26

Net Charge (pH 7.4) -1.49

Charge Density (pH 7.0) -0.1048

GRAVY Index0.66

Hydrophobic Moment 0.27

Boman Index0.35

Instability Index75.80

Aliphatic Index 65.00

Aromaticity 0.1667

Extinction Coeff. Reduced 1490.00

Extinction Coeff. Oxidized 1615.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 463.83

LogP -1.73

H-bond Donors 17.0

H-bond Acceptors 20.0

Rotatable Bonds 39.0

Heavy Atoms 97.0

Ring Count 4.0

Amide Bonds 11.0

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.

2D CHEMICAL STRUCTURE

Drag to move

Drag to move. Use the buttons to zoom.

RECORD: Rec_0063305 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/