Peptide Database

Peptide NameBasic phospholipase A2 myotoxin-I (MTX-I) (svPLA2) (EC 3.1.1.4) (Phosphatidylcholine 2-acylhydrolase)

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Antimicrobial ▸ Antifungal

Antimicrobial ▸ Antifungal ▸ Anti-Candida

Enzyme / Catalytic activity ▸ Hydrolase

Enzyme modulation ▸ Enzyme inhibition ▸ Blood coagulation cascade inhibitor

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Venom / Toxin ▸ General toxin ▸ Toxin

Standard StatusStandard

Sequence Length78 amino acids

Chemical FormulaC402H612N110O107S11

DescriptionStandard

        SLWEFGQMILKETGKLPFPYYGAYGCYCGWGGRRGPKDATDRCCYVHDCKQICECDKAAAVCFRERKYMAYLRVLCKK
    

Molecular Weight9050.55 Da

Isoelectric Point (pI)8.89

Net Charge (pH 7.0)5.46

Net Charge (pH 7.4) 5.04

Charge Density (pH 7.0) 0.0700

GRAVY Index-0.40

Hydrophobic Moment 0.66

Boman Index-0.08

Instability Index43.60

Aliphatic Index 53.85

Aromaticity 0.1538

Extinction Coeff. Reduced 21430.00

Extinction Coeff. Oxidized 21930.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 3504.35

LogP -27.38

H-bond Donors 134.0

H-bond Acceptors 125.0

Rotatable Bonds 295.0

Heavy Atoms 630.0

Ring Count 18.0

Amide Bonds 79.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0001759 VERIFIED: YES

Provenance & Taxonomy

OrganismBothrops brazili [Animal]

FamilyPhospholipase A2; Group II subfamily; D49 sub-subfamily

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antibiotic Antifungal Anti-Candida Anti-Gram-negative Hydrolase Blood coagulation cascade inhibitor Toxin Cytotoxic Non-hemolytic

TargetEscherichia coli (Gram-negative)

RECORD: Rec_0061910 VERIFIED: YES

Provenance & Taxonomy

OrganismBothrops brazili [Animal]

FamilyPhospholipase A2; Group II subfamily; D49 sub-subfamily

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antibiotic Antifungal Anti-Candida Anti-Gram-negative Hydrolase Blood coagulation cascade inhibitor Toxin Cytotoxic Non-hemolytic

TargetLeishmania

RECORD: Rec_0078385 VERIFIED: YES

Provenance & Taxonomy

OrganismBothrops brazili [Animal]

FamilyPhospholipase A2; Group II subfamily; D49 sub-subfamily

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antibiotic Antifungal Anti-Candida Anti-Gram-negative Hydrolase Blood coagulation cascade inhibitor Toxin Cytotoxic Non-hemolytic

TargetCandida albicans