MYP_028761
fStAx-3
Anticancer
Antimicrobial
Antimicrobial
▸
Antibacterial
Standard
16 amino acids
C76H125N23O27S
Standard
AENPESILDSHVQRVM
1825.01 Da
4.65
-2.11
-2.35
-0.1319
-0.50
0.46
-0.08
54.55
91.25
0.0000
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Amino Acid Composition
820.15
-9.09
27.0
27.0
60.0
127.0
2.0
17.0
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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RECORD: Rec_0191374
VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Axin-derived
32630
Structure & Mods
hydrocarbon-stapled side-chain cyclic peptide [Cyclic]
noncanonical stereochemical modification [Modified]
FITC-βAla labeling
Amidation
Stapled: Ⓧ(6) and Ⓧ (10) are cross-linked by hydrocarbon stapling
Bio-Activity Profile
β-catenin binding
Protein-binding
Wnt/β-catenin pathway inhibitor
Anticancer
β-catenin
fluorescence polarization β-catenin binding assay
RECORD: Rec_0433132
VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Axin-derived
Structure & Mods
hydrocarbon-stapled side-chain cyclic peptide [Cyclic]
noncanonical stereochemical modification [Modified]
FITC-βAla labeling
Amidation
Hydrocarbon-stapled side-chain crosslink at the fStAx-3 staple positions
Bio-Activity Profile
β-catenin binding
Protein-binding
Wnt/β-catenin pathway inhibitor
Anticancer
β-catenin
63±6 nM
Kd by direct fluorescence polarization binding assay