Peptide Database

Peptide NameBig endothelin-1

Function Ontology

Cardiovascular

Cardiovascular ▸ Vascular tone modulation ▸ Vasoactive peptide

Cardiovascular ▸ Vascular tone modulation ▸ Vasoconstrictor activity

Enzyme modulation ▸ Enzyme inhibition ▸ ACE inhibition ▸ ACE inhibitory

Hormonal / Endocrine ▸ Hormone peptide

Neurological / Signaling ▸ Neuromuscular and muscle activity ▸ Myotropic activity

Regulatory peptide ▸ Biological modulation

Standard StatusStandard

Sequence Length30 amino acids

Chemical FormulaC154H233N37O45S5

DescriptionStandard

        CSCSSLMDKECVYFCHLDIIWVNTPEHIVP
    

Molecular Weight3483.04 Da

Isoelectric Point (pI)4.72

Net Charge (pH 7.0)-3.10

Net Charge (pH 7.4) -3.47

Charge Density (pH 7.0) -0.1033

GRAVY Index0.40

Hydrophobic Moment 0.31

Boman Index0.23

Instability Index60.47

Aliphatic Index 94.00

Aromaticity 0.1000

Extinction Coeff. Reduced 6990.00

Extinction Coeff. Oxidized 7240.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1282.25

LogP -8.97

H-bond Donors 47.0

H-bond Acceptors 49.0

Rotatable Bonds 107.0

Heavy Atoms 241.0

Ring Count 8.0

Amide Bonds 30.0

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.

2D CHEMICAL STRUCTURE

Drag to move

Drag to move. Use the buttons to zoom.

RECORD: Rec_0084287 VERIFIED: YES

Provenance & Taxonomy

OrganismSus scrofa [Animal]

FamilyBig endothelin

Tax ID9823

Structure & Mods

Configdisulfide-constrained peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

Disulfide1-15; 3-11

Bio-Activity Profile

Function

Hormone Endocrine Vasoactive Vasoconstrictor Cardiovascular Myotropic Receptor modulation ACE inhibitory

Targetglomerular mesangial cells

Half-LifeMammalian: 1.2 hour; Yeast: >20 hour; E. coli: >10 hour

RECORD: Rec_0230861 VERIFIED: YES

Provenance & Taxonomy

OrganismSus scrofa [Animal]

FamilyEndothelin/sarafotoxin

Tax ID9823

Structure & Mods

Configdisulfide-constrained cyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

Disulfide1-15; 3-11

Bio-Activity Profile

Function

Vasoactive Hormone

RECORD: Rec_0296926 VERIFIED: YES

Provenance & Taxonomy

OrganismSus scrofa [Animal]

FamilyBig endothelin

Tax ID9823

Structure & Mods

Configdisulfide-constrained peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

Disulfide1-15; 3-11

Bio-Activity Profile

Function

Hormone Endocrine Vasoactive Vasoconstrictor Cardiovascular Myotropic Receptor modulation ACE inhibitory

Half-LifeMammalian: 1.2 hour; Yeast: >20 hour; E. coli: >10 hour