Peptide Database

Peptide NameBeta-defensin 114 (Beta-defensin 14) (DEFB-14) (Defensin; beta 114)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive

Antimicrobial ▸ Antibiotic activity

Antimicrobial ▸ Antifungal

Antimicrobial ▸ Antifungal ▸ Anti-Candida

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Standard StatusStandard

Sequence Length69 amino acids

Chemical FormulaC367H576N96O104S10

DescriptionStandard

        MRIFYYLHFLCYVTFILPATCTLVNADRCTKRYGRCKRDCLESEKQIDICSLPRKICCTEKLYEEDDMF
    

Molecular Weight8317.73 Da

Isoelectric Point (pI)7.50

Net Charge (pH 7.0)0.52

Net Charge (pH 7.4) 0.11

Charge Density (pH 7.0) 0.0075

GRAVY Index-0.16

Hydrophobic Moment 0.81

Boman Index-0.08

Instability Index61.93

Aliphatic Index 79.13

Aromaticity 0.1304

Extinction Coeff. Reduced 7450.00

Extinction Coeff. Oxidized 7950.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 3256.66

LogP -24.51

H-bond Donors 124.0

H-bond Acceptors 116.0

Rotatable Bonds 276.0

Heavy Atoms 577.0

Ring Count 12.0

Amide Bonds 70.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0091003 VERIFIED: YES

Provenance & Taxonomy

OrganismHomo sapiens [Animal]

FamilyBeta-defensin; Defensin

Tax ID9606

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antibiotic Defensin Antifungal Anti-Candida Anti-Gram-negative Anti-Gram-positive Non-hemolytic

TargetStaphylococcus aureus (Gram-positive)

RECORD: Rec_0306283 VERIFIED: YES