Peptide Database

Peptide NameSLAY-screened peptide P5012

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length20 amino acids

Chemical FormulaC126H168N26O29S

DescriptionStandard

        YRYLPLYFWGCPLYHTSTYV
    

Molecular Weight2542.90 Da

Isoelectric Point (pI)8.14

Net Charge (pH 7.0)0.83

Net Charge (pH 7.4) 0.56

Charge Density (pH 7.0) 0.0416

GRAVY Index0.00

Hydrophobic Moment 0.27

Boman Index0.27

Instability Index13.75

Aliphatic Index 73.00

Aromaticity 0.3500

Extinction Coeff. Reduced 12950.00

Extinction Coeff. Oxidized 12950.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 866.85

LogP -1.33

H-bond Donors 33.0

H-bond Acceptors 32.0

Rotatable Bonds 68.0

Heavy Atoms 182.0

Ring Count 11.0

Amide Bonds 19.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0045023 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/