Peptide Database

Peptide NameACE2 (24-36)(SAP5)

Function Ontology

Antimicrobial

Antiviral

Antiviral ▸ Anti-Coronavirus ▸ Anti-SARS-CoV

Antiviral ▸ Anti-Coronavirus ▸ Anti-SARS-CoV-2

Enzyme modulation ▸ Enzyme inhibition ▸ Infection inhibition

Membrane / Ion-channel modulation ▸ Sodium channel modulation ▸ Sodium channel inhibitor

Standard StatusStandard

Sequence Length13 amino acids

Chemical FormulaC70H105N19O21

DescriptionStandard

        QAKTFLDKFNHEA
    

Molecular Weight1548.70 Da

Isoelectric Point (pI)6.75

Net Charge (pH 7.0)-0.15

Net Charge (pH 7.4) -0.41

Charge Density (pH 7.0) -0.0116

GRAVY Index-0.98

Hydrophobic Moment 0.50

Boman Index-0.16

Instability Index12.19

Aliphatic Index 45.38

Aromaticity 0.1538

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 674.25

LogP -6.13

H-bond Donors 22.0

H-bond Acceptors 22.0

Rotatable Bonds 52.0

Heavy Atoms 110.0

Ring Count 3.0

Amide Bonds 14.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0418410 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyProtein-derived synthetic peptide

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Bio-Activity Profile

Function

Antiviral Anti-SARS-CoV-2 Infection inhibition

TargetSARS-CoV-2 | 293T/ACE2 cells

Activity7500 μM

MethodIC50

Half-LifeMammalian: 0.8 h; Yeast: 10 min; E. coli: >10 h

PaperRationally Designed ACE2-Derived Peptides Inhibit SARS-CoV-2. | Larue RC, Xing E, Kenney AD, Zhang Y, Tuazon JA, Li J, Yount JS, Li PK, Sharma A. | Bioconjug Chem. 2021 Jan 20;32(1):215-223. | DOI:10.1021/acs.bioconjchem.0c00664 | PMID:33356169 PMID33356169 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/33356169/

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