‹ ›
MYP_028689
← PREVIOUS NEXT → BACK
Basic Information
ACE2 (24-36)(SAP5)
Antimicrobial
Antiviral
Antiviral ▸ Anti-Coronavirus ▸ Anti-SARS-CoV
Antiviral ▸ Anti-Coronavirus ▸ Anti-SARS-CoV-2
Enzyme modulation ▸ Enzyme inhibition ▸ Infection inhibition
Membrane / Ion-channel modulation ▸ Sodium channel modulation ▸ Sodium channel inhibitor
Standard
13 amino acids
C70H105N19O21
Standard
Sequence
QAKTFLDKFNHEA
Physicochemical Analysis
1548.70 Da
6.75
-0.15
-0.41
-0.0116
-0.98
0.50
-0.16
12.19
45.38
0.1538
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
674.25
-6.13
22.0
22.0
52.0
110.0
3.0
14.0
Structural Visualization
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.
2D CHEMICAL STRUCTURE
Drag to move
Drag to move. Use the buttons to zoom.
Experimental Records
RECORD: Rec_0207288 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral
SARS-CoV-2 PsV
PMID33356169 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/33356169/
RECORD: Rec_0234525 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Anti-SARS-CoV-2
No nhibition of infection in 293T/ACE2/GFP cells up to 3 mM
PMID33356169 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/33356169/
RECORD: Rec_0320156 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Protein-derived synthetic peptide
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Anti-SARS-CoV Infection inhibition
SARS-CoV | 293T/ACE2 cells
3000 μM
% inhibition
Mammalian: 0.8 h; Yeast: 10 min; E. coli: >10 h
PaperRationally Designed ACE2-Derived Peptides Inhibit SARS-CoV-2. | Larue RC, Xing E, Kenney AD, Zhang Y, Tuazon JA, Li J, Yount JS, Li PK, Sharma A. | Bioconjug Chem. 2021 Jan 20;32(1):215-223. | DOI:10.1021/acs.bioconjchem.0c00664 | PMID:33356169 PMID33356169 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/33356169/
RECORD: Rec_0354817 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Anti-SARS-CoV-2
Virus
PMID33356169 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/33356169/
RECORD: Rec_0369073 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Protein-derived synthetic peptide
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Anti-VSV Infection inhibition
Vesicular Stomatitis Virus (VSV) | 293T/ACE2 cells
Mammalian: 0.8 h; Yeast: 10 min; E. coli: >10 h
PaperRationally Designed ACE2-Derived Peptides Inhibit SARS-CoV-2. | Larue RC, Xing E, Kenney AD, Zhang Y, Tuazon JA, Li J, Yount JS, Li PK, Sharma A. | Bioconjug Chem. 2021 Jan 20;32(1):215-223. | DOI:10.1021/acs.bioconjchem.0c00664 | PMID:33356169 PMID33356169 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/33356169/
FIRST PREV 1 2 3 NEXT LAST
Showing 5 records on this page · Page 2 of 3