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MYP_028689
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Basic Information
ACE2 (24-36)(SAP5)
Antimicrobial
Antiviral
Antiviral ▸ Anti-Coronavirus ▸ Anti-SARS-CoV
Antiviral ▸ Anti-Coronavirus ▸ Anti-SARS-CoV-2
Enzyme modulation ▸ Enzyme inhibition ▸ Infection inhibition
Membrane / Ion-channel modulation ▸ Sodium channel modulation ▸ Sodium channel inhibitor
Standard
13 amino acids
C70H105N19O21
Standard
Sequence
QAKTFLDKFNHEA
Physicochemical Analysis
1548.70 Da
6.75
-0.15
-0.41
-0.0116
-0.98
0.50
-0.16
12.19
45.38
0.1538
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
674.25
-6.13
22.0
22.0
52.0
110.0
3.0
14.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0097332 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Anti-SARS-CoV-2 Antiviral
SARS-CoV-2 Spike-pseudotyped virus; 293T/ACE2 cells
>7.5 mM
pseudovirus infection inhibition (IC50)
PMID33356169 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/33356169/
RECORD: Rec_0105561 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Protein-derived synthetic peptide
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Anti-SARS-CoV-2 Infection inhibition
SARS-CoV-2 Spike-pseudotyped virus; 293T/ACE2/GFP cells
pseudovirus infection inhibition assay (no inhibition up to 3 mM)
Mammalian: 0.8 h; Yeast: 10 min; E. coli: >10 h
PaperRationally Designed ACE2-Derived Peptides Inhibit SARS-CoV-2. | Larue RC, Xing E, Kenney AD, Zhang Y, Tuazon JA, Li J, Yount JS, Li PK, Sharma A. | Bioconjug Chem. 2021 Jan 20;32(1):215-223. | DOI:10.1021/acs.bioconjchem.0c00664 | PMID:33356169 PMID33356169 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/33356169/
RECORD: Rec_0119548 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Anti-SARS-CoV-2 Antiviral
SARS-CoV Spike-pseudotyped virus; 293T/ACE2 cells
pseudovirus infection inhibition assay
PMID33356169 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/33356169/
RECORD: Rec_0163232 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Anti-SARS-CoV-2
VSV-G pseudotyped virus; 293T/ACE2 cells
pseudovirus infection inhibition assay (no significant inhibition up to 3 mM)
PMID33356169 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/33356169/
RECORD: Rec_0201102 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
ACE2-derived peptide
9606
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral
SARS-CoV-2 Spike-pseudotyped virus; 293T/ACE2 cells
>7.5 mM
pseudovirus infection inhibition (IC50)
PaperRationally designed ACE2-derived peptides inhibit SARS-CoV-2 PMID33356169 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/33356169/
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